JUN
Transcription factor Jun
Also known as: AP-1, c-Jun, JUN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P05412
- Gene
- JUN
- Ensembl
- ENSG00000177606
- Chromosome
- 1
- Canonical length
- 331 aa
- Protein class
- Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
331 residues, UniProt reviewed canonical sequence.
>P05412|JUN
1 MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL
61 LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE
121 LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA
181 LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP
241 PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM
301 LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT FLocalizationUniProt · AlphaFold · HPA
Whether an antibody against JUN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 192 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 192 nTPM
- thyroid gland: 178 nTPM
- breast: 171 nTPM
- ovary: 162 nTPM
- pancreas: 154 nTPM
- fallopian tube: 149 nTPM
Single-cell type
- ovarian stromal cells: 4,609 nCPM
- breast lactating cells: 3,948 nCPM
- epididymal principal cells: 3,796 nCPM
- pancreatic duct cells: 3,632 nCPM
- epididymal efferent duct absorptive cells: 2,628 nCPM
- decidual stromal cells: 2,626 nCPM
Immune cell
- naive B-cell: 0.6 nTPM
- NK-cell: 0.6 nTPM
- memory B-cell: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- gdT-cell: 0.2 nTPM
- memory CD4 T-cell: 0.2 nTPM
Brain region
- cerebellum: 49 nTPM
- cerebral cortex: 44 nTPM
- hypothalamus: 41 nTPM
- basal ganglia: 40 nTPM
- hippocampal formation: 39 nTPM
- white matter: 39 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about JUN.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 23 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0.06
- gnomAD missense Z
- 1.19
- DepMap mean gene effect
- -0.3
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- angiogenesis
- apoptotic process
- axon regeneration
- cell population proliferation
- cellular response to anisomycin
- cellular response to calcium ion
- eyelid development in camera-type eye
- host-mediated activation of viral transcription
- host-mediated suppression of viral transcription
- integrated stress response signaling
- JNK cascade
- leading edge cell differentiation
- liver development
- microglial cell activation
- monocyte differentiation
- negative regulation of cell population proliferation
- negative regulation of DNA binding
- negative regulation of DNA-templated transcription
- negative regulation of neuron apoptotic process
- negative regulation of transcription by RNA polymerase II
- outflow tract morphogenesis
- positive regulation of DNA-templated transcription
- positive regulation of DNA-templated transcription initiation
- positive regulation of endothelial cell proliferation
- positive regulation of epithelial cell migration
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of fibroblast proliferation
- positive regulation of miRNA transcription
- positive regulation of transcription by RNA polymerase II
- positive regulation of vascular associated smooth muscle cell proliferation
- regulation of cell cycle
- regulation of cell population proliferation
- regulation of transcription by RNA polymerase II
- release from viral latency
- response to endoplasmic reticulum stress
- response to muscle stretch
- response to steroid hormone
- response to xenobiotic stimulus
- SMAD protein signal transduction
- transforming growth factor beta receptor signaling pathway
Molecular functions
- cAMP response element binding
- chromatin binding
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- enzyme binding
- general transcription initiation factor binding
- GTPase activator activity
- identical protein binding
- R-SMAD binding
- RNA binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
- ubiquitin protein ligase binding
- ubiquitin-like protein ligase binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of JUN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads JUN as an antibody target. Whether an autoantibody or antibody against JUN could matter depends on whether native JUN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
JUN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label JUN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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