Seroatlas · Human Serome Atlas

JDP2

Jun dimerization protein 2

Also known as: JDP2_HUMAN, JUNDM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WYK2
Gene: JDP2
Ensembl: ENSG00000140044
Chromosome: 14
Canonical length: 163 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q8WYK2|JDP2
     1  MMPGQIPDPS VTTGSLPGLG PLTGLPSSAL TVEELKYADI RNLGAMIAPL HFLEVKLGKR
    61  PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL QRESERLELM NAELKTQIEE
   121  LKQERQQLIL MLNRHRPTCI VRTDSVKTPE SEGNPLLEQL EKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JDP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 74 nTPM
spleen: 61 nTPM
adipose tissue: 49 nTPM
lung: 44 nTPM
breast: 38 nTPM
heart muscle: 37 nTPM

Single-cell type

monocytes: 321 nCPM
neutrophil progenitors: 315 nCPM
kupffer cells: 283 nCPM
neutrophils: 272 nCPM
monocyte progenitors: 241 nCPM
alveolar cells type 2: 205 nCPM

Immune cell

non-classical monocyte: 13 nTPM
memory B-cell: 12 nTPM
intermediate monocyte: 8.1 nTPM
neutrophil: 7.7 nTPM
naive B-cell: 5.1 nTPM
classical monocyte: 4.5 nTPM

Brain region

thalamus: 38 nTPM
medulla oblongata: 36 nTPM
hypothalamus: 35 nTPM
cerebral cortex: 34 nTPM
hippocampal formation: 33 nTPM
amygdala: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.36
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JDP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JDP2 as an antibody target. Whether an autoantibody or antibody against JDP2 could matter depends on whether native JDP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JDP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JDP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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