CEBPG
CCAAT/enhancer-binding protein gamma
Also known as: CEBPG_HUMAN, GPE1BP, IG/EBP-1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P53567
- Gene
- CEBPG
- Ensembl
- ENSG00000153879
- Chromosome
- 19
- Canonical length
- 150 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
Canonical amino-acid sequenceUniProt
150 residues, UniProt reviewed canonical sequence.
>P53567|CEBPG
1 MSKISQQNST PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVAPSK QSKKSSPMDR
61 NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE NERLEAKIKL LTKELSVLKD
121 LFLEHAHNLA DNVQSISTEN TTADGDNAGQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CEBPG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 44 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 44 nTPM
- tongue: 41 nTPM
- small intestine: 33 nTPM
- liver: 32 nTPM
- duodenum: 32 nTPM
- colon: 28 nTPM
Single-cell type
- esophageal apical cells: 177 nCPM
- colonocytes: 127 nCPM
- late primary spermatocytes: 124 nCPM
- epididymal efferent duct ciliated cells: 123 nCPM
- suprabasal keratinocytes: 112 nCPM
- enterocytes: 111 nCPM
Immune cell
- non-classical monocyte: 19 nTPM
- intermediate monocyte: 12 nTPM
- myeloid DC: 10 nTPM
- classical monocyte: 9.7 nTPM
- basophil: 7.5 nTPM
- T-reg: 6 nTPM
Brain region
- hypothalamus: 25 nTPM
- thalamus: 24 nTPM
- spinal cord: 24 nTPM
- white matter: 22 nTPM
- medulla oblongata: 21 nTPM
- midbrain: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0.44
- gnomAD missense Z
- -0.06
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- B cell differentiation
- DNA-templated transcription
- enucleate erythrocyte differentiation
- immune response
- integrated stress response signaling
- liver development
- mRNA metabolic process
- natural killer cell mediated cytotoxicity
- negative regulation of DNA-binding transcription factor activity
- positive regulation of DNA binding
- positive regulation of DNA repair
- positive regulation of DNA-binding transcription factor activity
- positive regulation of transcription by RNA polymerase II
- positive regulation of type II interferon production
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- identical protein binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CEBPG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CEBPG as an antibody target. Whether an autoantibody or antibody against CEBPG could matter depends on whether native CEBPG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CEBPG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CEBPG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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