Seroatlas · Human Serome Atlas

COPS5

COP9 signalosome complex subunit 5

Also known as: CSN5, CSN5_HUMAN, JAB1, MOV-34, SGN5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92905
Gene
COPS5
Ensembl
ENSG00000121022
Chromosome
8
Canonical length
334 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q92905|COPS5
     1  MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL
    61  ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY
   121  IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK
   181  VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL
   241  LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL
   301  AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
153 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 153 nTPM
  • tongue: 126 nTPM
  • heart muscle: 109 nTPM
  • liver: 66 nTPM
  • spinal cord: 64 nTPM
  • parathyroid gland: 55 nTPM

Single-cell type

  • late spermatids: 758 nCPM
  • early spermatids: 453 nCPM
  • late primary spermatocytes: 388 nCPM
  • cardiomyocytes: 158 nCPM
  • cytotrophoblasts: 115 nCPM
  • migrating cytotrophoblasts: 102 nCPM

Immune cell

  • basophil: 67 nTPM
  • eosinophil: 65 nTPM
  • myeloid DC: 64 nTPM
  • non-classical monocyte: 57 nTPM
  • intermediate monocyte: 56 nTPM
  • T-reg: 53 nTPM

Brain region

  • white matter: 47 nTPM
  • cerebellum: 45 nTPM
  • spinal cord: 43 nTPM
  • hypothalamus: 42 nTPM
  • pons: 41 nTPM
  • thalamus: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
3.44
DepMap mean gene effect
-1.79
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPS5 as an antibody target. Whether an autoantibody or antibody against COPS5 could matter depends on whether native COPS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPS5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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