Seroatlas · Human Serome Atlas

COP1

E3 ubiquitin-protein ligase COP1

Also known as: CFAP78, COP1_HUMAN, FAP78, FLJ10416, RFWD2, RNF200

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHY2
Gene
COP1
Ensembl
ENSG00000143207
Chromosome
1
Canonical length
731 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

731 residues, UniProt reviewed canonical sequence.

>Q8NHY2|COP1
     1  MSGSRQAGSG SAGTSPGSSA ASSVTSASSS LSSSPSPPSV AVSAAALVSG GVAQAAGSGG
    61  LGGPVRPVLV APAVSGSGGG AVSTGLSRHS CAARPSAGVG GSSSSLGSGS RKRPLLAPLC
   121  NGLINSYEDK SNDFVCPICF DMIEEAYMTK CGHSFCYKCI HQSLEDNNRC PKCNYVVDNI
   181  DHLYPNFLVN ELILKQKQRF EEKRFKLDHS VSSTNGHRWQ IFQDWLGTDQ DNLDLANVNL
   241  MLELLVQKKK QLEAESHAAQ LQILMEFLKV ARRNKREQLE QIQKELSVLE EDIKRVEEMS
   301  GLYSPVSEDS TVPQFEAPSP SHSSIIDSTE YSQPPGFSGS SQTKKQPWYN STLASRRKRL
   361  TAHFEDLEQC YFSTRMSRIS DDSRTASQLD EFQECLSKFT RYNSVRPLAT LSYASDLYNG
   421  SSIVSSIEFD RDCDYFAIAG VTKKIKVYEY DTVIQDAVDI HYPENEMTCN SKISCISWSS
   481  YHKNLLASSD YEGTVILWDG FTGQRSKVYQ EHEKRCWSVD FNLMDPKLLA SGSDDAKVKL
   541  WSTNLDNSVA SIEAKANVCC VKFSPSSRYH LAFGCADHCV HYYDLRNTKQ PIMVFKGHRK
   601  AVSYAKFVSG EEIVSASTDS QLKLWNVGKP YCLRSFKGHI NEKNFVGLAS NGDYIACGSE
   661  NNSLYLYYKG LSKTLLTFKF DTVKSVLDKD RKEDDTNEFV SAVCWRALPD GESNVLIAAN
   721  SQGTIKVLEL V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • skin: 17 nTPM
  • colon: 17 nTPM
  • bone marrow: 16 nTPM
  • rectum: 16 nTPM
  • spleen: 16 nTPM
  • tonsil: 16 nTPM

Single-cell type

  • neutrophils: 2,758 nCPM
  • neutrophil progenitors: 1,336 nCPM
  • monocytes: 496 nCPM
  • monocyte progenitors: 487 nCPM
  • urothelial cells: 366 nCPM
  • microglia: 363 nCPM

Immune cell

  • neutrophil: 14 nTPM
  • eosinophil: 12 nTPM
  • basophil: 8.6 nTPM
  • intermediate monocyte: 3.7 nTPM
  • non-classical monocyte: 3.4 nTPM
  • classical monocyte: 3 nTPM

Brain region

  • cerebellum: 39 nTPM
  • cerebral cortex: 34 nTPM
  • white matter: 34 nTPM
  • choroid plexus: 33 nTPM
  • hippocampal formation: 33 nTPM
  • basal ganglia: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COP1 as an antibody target. Whether an autoantibody or antibody against COP1 could matter depends on whether native COP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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