Seroatlas · Human Serome Atlas

PRR7

Proline-rich protein 7

Also known as: MGC10772, PRR7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB68
Gene: PRR7
Ensembl: ENSG00000131188
Chromosome: 5
Canonical length: 274 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein ligase binding activity. Involved in positive regulation of apoptotic process and regulation of transcription by RNA polymerase I. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q8TB68|PRR7
     1  MVMSQGTYTF LTCFAGFWLI WGLIVLLCCF CSFLRRRLKR RQEERLREQN LRALELEPLE
    61  LEGSLAGSPP GLAPPQPPPH RSRLEAPAHA HSHPHVHVHP LLHHGPAQPH AHAHPHPHHH
   121  ALPHPPPTHL SVPPRPWSYP RQAESDMSKP PCYEEAVLMA EPPPPYSEVL TDTRGLYRKI
   181  VTPFLSRRDS AEKQEQPPPS YKPLFLDRGY TSALHLPSAP RPAPPCPALC LQADRGRRVF
   241  PSWTDSELSS REPLEHGAWR LPVSIPLFGR TTAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 32 nTPM
hippocampal formation: 28 nTPM
amygdala: 21 nTPM
cerebral cortex: 19 nTPM
hypothalamus: 14 nTPM
pituitary gland: 10 nTPM

Single-cell type

megakaryocytes: 124 nCPM
fallopian tube ciliated cells: 68 nCPM
respiratory ciliated cells: 64 nCPM
platelets: 61 nCPM
suprabasal keratinocytes: 46 nCPM
epididymal efferent duct ciliated cells: 46 nCPM

Immune cell

eosinophil: 9.7 nTPM
MAIT T-cell: 5.5 nTPM
memory CD8 T-cell: 3.9 nTPM
neutrophil: 3.7 nTPM
naive CD8 T-cell: 3.1 nTPM
naive B-cell: 2.8 nTPM

Brain region

cerebral cortex: 55 nTPM
hippocampal formation: 54 nTPM
basal ganglia: 42 nTPM
amygdala: 39 nTPM
hypothalamus: 32 nTPM
choroid plexus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.87
gnomAD missense Z: 1.29
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WW domain-binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRR7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR7 as an antibody target. Whether an autoantibody or antibody against PRR7 could matter depends on whether native PRR7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR7 is annotated at the cell surface, where native PRR7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRR7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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