Seroatlas · Human Serome Atlas

RNF187

E3 ubiquitin-protein ligase RNF187

Also known as: RACO-1, RACO1, RN187_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TA31
Gene: RNF187
Ensembl: ENSG00000168159
Chromosome: 1
Canonical length: 235 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables ubiquitin-protein transferase activity. Involved in positive regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q5TA31|RNF187
     1  MALPAGPAEA ACALCQRAPR EPVRADCGHR FCRACVVRFW AEEDGPFPCP ECADDCWQRA
    61  VEPGRPPLSR RLLALEEAAA APARDGPASE AALQLLCRAD AGPLCAACRM AAGPEPPEWE
   121  PRWRKALRGK ENKGSVEIMR KDLNDARDLH GQAESAAAVW KGHVMDRRKK ALTDYKKLRA
   181  FFVEEEEHFL QEAEKEEGLP EDELADPTER FRSLLQAVSE LEKKHRNLGL SMLLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF187 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 127 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 127 nTPM
amygdala: 95 nTPM
cerebellum: 94 nTPM
basal ganglia: 93 nTPM
hippocampal formation: 91 nTPM
hypothalamus: 87 nTPM

Single-cell type

other brain neurons: 45 nCPM
brain excitatory neurons: 33 nCPM
brain inhibitory neurons: 30 nCPM
ependymal cells: 23 nCPM
oligodendrocytes: 22 nCPM
podocytes: 17 nCPM

Immune cell

eosinophil: 3.6 nTPM
intermediate monocyte: 1 nTPM
memory CD8 T-cell: 1 nTPM
naive B-cell: 1 nTPM
non-classical monocyte: 0.8 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

cerebral cortex: 64 nTPM
medulla oblongata: 55 nTPM
white matter: 54 nTPM
thalamus: 53 nTPM
pons: 52 nTPM
hypothalamus: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.1
gnomAD missense Z: 1.29

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF187 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF187 as an antibody target. Whether an autoantibody or antibody against RNF187 could matter depends on whether native RNF187 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF187 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF187 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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