Seroatlas · Human Serome Atlas

PLEKHO1

Pleckstrin homology domain-containing family O member 1

Also known as: CKIP-1, OC120, PKHO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53GL0
Gene
PLEKHO1
Ensembl
ENSG00000023902
Chromosome
1
Canonical length
409 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in regulation of myoblast fusion. Predicted to act upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be active in muscle cell projection membrane and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q53GL0|PLEKHO1
     1  MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG DQLYISEKEV
    61  KDEKNIQEVF DLSDYEKCEE LRKSKSRSKK NHSKFTLAHS KQPGNTAPNL IFLAVSPEEK
   121  ESWINALNSA ITRAKNRILD EVTVEEDSYL AHPTRDRAKI QHSRRPPTRG HLMAVASTST
   181  SDGMLTLDLI QEEDPSPEEP TSCAESFRVD LDKSVAQLAG SRRRADSDRI QPSADRASSL
   241  SRPWEKTDKG ATYTPQAPKK LTPTEKGRCA SLEEILSQRD AASARTLQLR AEEPPTPALP
   301  NPGQLSRIQD LVARKLEETQ ELLAEVQGLG DGKRKAKDPP RSPPDSESEQ LLLETERLLG
   361  EASSNWSQAK RVLQEVRELR DLYRQMDLQT PDSHLRQTTP HSQYRKSLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
189 nTPM

Expression across tissuesHPA

Tissue

  • colon: 189 nTPM
  • blood vessel: 98 nTPM
  • urinary bladder: 92 nTPM
  • testis: 77 nTPM
  • spleen: 56 nTPM
  • small intestine: 54 nTPM

Single-cell type

  • platelets: 1,195 nCPM
  • late spermatids: 526 nCPM
  • smooth muscle cells: 349 nCPM
  • late primary spermatocytes: 292 nCPM
  • early spermatids: 256 nCPM
  • cdc: 226 nCPM

Immune cell

  • neutrophil: 31 nTPM
  • plasmacytoid DC: 27 nTPM
  • classical monocyte: 26 nTPM
  • intermediate monocyte: 25 nTPM
  • non-classical monocyte: 24 nTPM
  • memory B-cell: 20 nTPM

Brain region

  • cerebral cortex: 29 nTPM
  • cerebellum: 26 nTPM
  • basal ganglia: 21 nTPM
  • medulla oblongata: 21 nTPM
  • amygdala: 20 nTPM
  • hippocampal formation: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.48
gnomAD missense Z
0.07
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHO1 as an antibody target. Whether an autoantibody or antibody against PLEKHO1 could matter depends on whether native PLEKHO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHO1 is annotated at the cell surface, where native PLEKHO1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEKHO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLEKHO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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