Seroatlas · Human Serome Atlas

MYBBP1A

Myb-binding protein 1A

Also known as: FLJ37886, MBB1A_HUMAN, P160, PAP2, Pol5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQG0
Gene: MYBBP1A
Ensembl: ENSG00000132382
Chromosome: 17
Canonical length: 1328 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Vesicles

OverviewNCBI Gene

This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

1328 residues, UniProt reviewed canonical sequence.

>Q9BQG0|MYBBP1A
     1  MESRDPAQPM SPGEATQSGA RPADRYGLLK HSREFLDFFW DIAKPEQETR LAATEKLLEY
    61  LRGRPKGSEM KYALKRLITG LGVGRETARP CYSLALAQLL QSFEDLPLCS ILQQIQEKYD
   121  LHQVKKAMLR PALFANLFGV LALFQSGRLV KDQEALMKSV KLLQALAQYQ NHLQEQPRKA
   181  LVDILSEVSK ATLQEILPEV LKADLNIILS SPEQLELFLL AQQKVPSKLK KLVGSVNLFS
   241  DENVPRLVNV LKMAASSVKK DRKLPAIALD LLRLALKEDK FPRFWKEVVE QGLLKMQFWP
   301  ASYLCFRLLG AALPLLTKEQ LHLVMQGDVI RHYGEHVCTA KLPKQFKFAP EMDDYVGTFL
   361  EGCQDDPERQ LAVLVAFSSV TNQGLPVTPT FWRVVRFLSP PALQGYVAWL RAMFLQPDLD
   421  SLVDFSTNNQ KKAQDSSLHM PERAVFRLRK WIIFRLVSIV DSLHLEMEEA LTEQVARFCL
   481  FHSFFVTKKP TSQIPETKHP FSFPLENQAR EAVSSAFFSL LQTLSTQFKQ APGQTQGGQP
   541  WTYHLVQFAD LLLNHSHNVT TVTPFTAQQR QAWDRMLQTL KELEAHSAEA RAAAFQHLLL
   601  LVGIHLLKSP AESCDLLGDI QTCIRKSLGE KPRRSRTKTI DPQEPPWVEV LVEILLALLA
   661  QPSHLMRQVA RSVFGHICSH LTPRALQLIL DVLNPETSED ENDRVVVTDD SDERRLKGAE
   721  DKSEEGEDNR SSESEEESEG EESEEEERDG DVDQGFREQL MTVLQAGKAL GGEDSENEEE
   781  LGDEAMMALD QSLASLFAEQ KLRIQARRDE KNKLQKEKAL RRDFQIRVLD LVEVLVTKQP
   841  ENALVLELLE PLLSIIRRSL RSSSSKQEQD LLHKTARIFT HHLCRARRYC HDLGERAGAL
   901  HAQVERLVQQ AGRQPDSPTA LYHFNASLYL LRVLKGNTAE GCVHETQEKQ KAGTDPSHMP
   961  TGPQAASCLD LNLVTRVYST ALSSFLTKRN SPLTVPMFLS LFSRHPVLCQ SLLPILVQHI
  1021  TGPVRPRHQA CLLLQKTLSM REVRSCFEDP EWKQLMGQVL AKVTENLRVL GEAQTKAQHQ
  1081  QALSSLELLN VLFRTCKHEK LTLDLTVLLG VLQGQQQSLQ QGAHSTGSSR LHDLYWQAMK
  1141  TLGVQRPKLE KKDAKEIPSA TQSPISKKRK KKGFLPETKK RKKRKSEDGT PAEDGTPAAT
  1201  GGSQPPSMGR KKRNRTKAKV PAQANGTPTT KSPAPGAPTR SPSTPAKSPK LQKKNQKPSQ
  1261  VNGAPGSPTE PAGQKQHQKA LPKKGVLGKS PLSALARKKA RLSLVIRSPS LLQSGAKKKA
  1321  QVRKAGKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYBBP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 26 nTPM
pancreas: 24 nTPM
skin: 22 nTPM
salivary gland: 18 nTPM
esophagus: 17 nTPM
prostate: 17 nTPM

Single-cell type

differentiating spermatogonia: 26 nCPM
esophageal basal cells: 26 nCPM
erythrocyte progenitors: 24 nCPM
alveolar cells type 1: 24 nCPM
oocytes: 23 nCPM
suprabasal keratinocytes: 23 nCPM

Immune cell

MAIT T-cell: 3.4 nTPM
non-classical monocyte: 3.4 nTPM
memory CD8 T-cell: 3.1 nTPM
gdT-cell: 2.9 nTPM
memory B-cell: 2.9 nTPM
myeloid DC: 2.9 nTPM

Brain region

cerebral cortex: 29 nTPM
medulla oblongata: 25 nTPM
midbrain: 25 nTPM
hypothalamus: 23 nTPM
hippocampal formation: 22 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -2.75
DepMap mean gene effect: -0.55
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
DNA polymerase V/Myb-binding protein 1A
DNA polymerase phi

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYBBP1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYBBP1A as an antibody target. Whether an autoantibody or antibody against MYBBP1A could matter depends on whether native MYBBP1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYBBP1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYBBP1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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