ATF3
Cyclic AMP-dependent transcription factor ATF-3
Also known as: ATF3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P18847
- Gene
- ATF3
- Ensembl
- ENSG00000162772
- Chromosome
- 1
- Canonical length
- 181 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli,Golgi apparatus,Vesicles,Centrosome,Basal body
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Canonical amino-acid sequenceUniProt
181 residues, UniProt reviewed canonical sequence.
>P18847|ATF3
1 MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS
61 ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK
121 LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ
181 SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ATF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 292 nTPM
Expression across tissuesHPA
Tissue
- smooth muscle: 292 nTPM
- urinary bladder: 262 nTPM
- thyroid gland: 170 nTPM
- adipose tissue: 168 nTPM
- fallopian tube: 154 nTPM
- skin: 152 nTPM
Single-cell type
- endometrial luminal cells: 1,837 nCPM
- epididymal basal cells: 1,805 nCPM
- breast secretory cells: 1,395 nCPM
- endometrial glandular cells: 1,350 nCPM
- fallopian secretory cells: 1,313 nCPM
- epididymal efferent duct absorptive cells: 1,271 nCPM
Immune cell
- basophil: 6.5 nTPM
- non-classical monocyte: 6.4 nTPM
- intermediate monocyte: 4 nTPM
- myeloid DC: 1.6 nTPM
- plasmacytoid DC: 0.8 nTPM
- classical monocyte: 0.7 nTPM
Brain region
- white matter: 28 nTPM
- medulla oblongata: 22 nTPM
- hypothalamus: 21 nTPM
- thalamus: 18 nTPM
- basal ganglia: 15 nTPM
- pons: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.89
- gnomAD pLI
- 0.09
- gnomAD missense Z
- 0.7
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to amino acid starvation
- endoplasmic reticulum unfolded protein response
- gluconeogenesis
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of transcription by RNA polymerase II
- positive regulation of cell population proliferation
- positive regulation of gene expression
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- response to endoplasmic reticulum stress
- response to type II interferon
- skeletal muscle cell differentiation
- transforming growth factor beta receptor signaling pathway
- positive regulation of TRAIL-activated apoptotic signaling pathway
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- identical protein binding
- protein heterodimerization activity
- protein homodimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ATF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ATF3 as an antibody target. Whether an autoantibody or antibody against ATF3 could matter depends on whether native ATF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ATF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ATF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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