APLP2

Protein identityUniProt · HPA

UniProt accession

Q06481

Gene

APLP2

Ensembl

ENSG00000084234

Chromosome

11

Canonical length

763 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

763 residues, UniProt reviewed canonical sequence.

>Q06481|APLP2
     1  MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
    61  MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK
   121  KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT
   181  LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF
   241  PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK
   301  EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
   361  KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
   421  NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ
   481  SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
   541  NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH
   601  PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD
   661  VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ
   721  YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APLP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

570 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.39

gnomAD pLI

0.38

gnomAD missense Z

0

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axonogenesis
• central nervous system development
• G protein-coupled receptor signaling pathway

Molecular functions

• DNA binding
• heparin binding
• identical protein binding
• serine-type endopeptidase inhibitor activity
• transition metal ion binding

Cellular components

• endoplasmic reticulum lumen
• extracellular exosome
• membrane
• nucleus
• plasma membrane
• platelet alpha granule membrane

Protein domainsUniProt · Pfam · InterPro

• Pancreatic trypsin inhibitor Kunitz domain
• Amyloidogenic glycoprotein, extracellular
• Amyloidogenic glycoprotein
• Amyloidogenic glycoprotein, copper-binding
• PH-like domain superfamily
• Amyloidogenic glycoprotein, heparin-binding
• Beta-amyloid precursor protein C-terminal
• Amyloidogenic glycoprotein, copper-binding domain conserved site
• Amyloidogenic glycoprotein, intracellular domain, conserved site
• Proteinase inhibitor I2, Kunitz, conserved site
• Amyloidogenic glycoprotein, E2 domain
• E2 domain superfamily
• Amyloidogenic glycoprotein, heparin-binding domain superfamily
• Amyloidogenic glycoprotein, copper-binding domain superfamily
• Pancreatic trypsin inhibitor Kunitz domain superfamily
• Kunitz/Bovine pancreatic trypsin inhibitor domain
• Amyloid A4 N-terminal heparin-binding
• Beta-amyloid precursor protein C-terminus
• Copper-binding of amyloid precursor, CuBD
• E2 domain of amyloid precursor protein

KeywordsUniProt

• Cell membrane
• Copper
• Disulfide bond
• DNA-binding
• Glycoprotein
• Membrane
• Metal-binding
• Nucleus
• Phosphoprotein
• Protease inhibitor
• Proteoglycan
• Serine protease inhibitor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of APLP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CPEB1
• APBB3
• APBB2
• APBB1
• JUN