ATF7
Cyclic AMP-dependent transcription factor ATF-7
Also known as: ATF7_HUMAN, ATFA
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P17544
- Gene
- ATF7
- Ensembl
- ENSG00000170653
- Chromosome
- 12
- Canonical length
- 483 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
483 residues, UniProt reviewed canonical sequence.
>P17544|ATF7
1 MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN
61 CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS TPDIKIKEEE PVEVDSSPPD
121 SPASSPCSPP LKEKEVTPKP VLISTPTPTI VRPGSLPLHL GYDPLHPTLP SPTSVITQAP
181 PSNRQMGSPT GSLPLVMHLA NGQTMPVLPG PPVQMPSVIS LARPVSMVPN IPGIPGPPVN
241 SSGSISPSGH PIPSEAKMRL KATLTHQVSS INGGCGMVVG TASTMVTARP EQSQILIQHP
301 DAPSPAQPQV SPAQPTPSTG GRRRRTVDED PDERRQRFLE RNRAAASRCR QKRKLWVSSL
361 EKKAEELTSQ NIQLSNEVTL LRNEVAQLKQ LLLAHKDCPV TALQKKTQGY LESPKESSEP
421 TGSPAPVIQH SSATAPSNGL SVRSAAEAVA TSVLTQMASQ RTELSMPIQS HVIMTPQSQS
481 AGRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ATF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 34 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 34 nTPM
- skeletal muscle: 29 nTPM
- adipose tissue: 25 nTPM
- smooth muscle: 25 nTPM
- skin: 24 nTPM
- endometrium: 23 nTPM
Single-cell type
- oligodendrocytes: 206 nCPM
- choroid plexus epithelial cells: 179 nCPM
- astrocytes: 148 nCPM
- bergmann glia: 147 nCPM
- ependymal cells: 106 nCPM
- microglia: 103 nCPM
Immune cell
- intermediate monocyte: 19 nTPM
- basophil: 15 nTPM
- NK-cell: 14 nTPM
- non-classical monocyte: 14 nTPM
- classical monocyte: 14 nTPM
- eosinophil: 14 nTPM
Brain region
- white matter: 68 nTPM
- cerebellum: 65 nTPM
- medulla oblongata: 54 nTPM
- cerebral cortex: 52 nTPM
- basal ganglia: 49 nTPM
- thalamus: 47 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.21
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.28
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
Molecular functions
- cAMP response element binding
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- enzyme binding
- mitogen-activated protein kinase binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- transcription coactivator binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ATF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ATF7 as an antibody target. Whether an autoantibody or antibody against ATF7 could matter depends on whether native ATF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ATF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ATF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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