Seroatlas · Human Serome Atlas

NRIP1

Nuclear receptor-interacting protein 1

Also known as: NRIP1_HUMAN, RIP140

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48552
Gene: NRIP1
Ensembl: ENSG00000180530
Chromosome: 21
Canonical length: 1158 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1158 residues, UniProt reviewed canonical sequence.

>P48552|NRIP1
     1  MTHGEELGSD VHQDSIVLTY LEGLLMHQAA GGSGTAVDKK SAGHNEEDQN FNISGSAFPT
    61  CQSNGPVLNT HTYQGSGMLH LKKARLLQSS EDWNAAKRKR LSDSIMNLNV KKEALLAGMV
   121  DSVPKGKQDS TLLASLLQSF SSRLQTVALS QQIRQSLKEQ GYALSHDSLK VEKDLRCYGV
   181  ASSHLKTLLK KSKVKDQKPD TNLPDVTKNL IRDRFAESPH HVGQSGTKVM SEPLSCAARL
   241  QAVASMVEKR ASPATSPKPS VACSQLALLL SSEAHLQQYS REHALKTQNA NQAASERLAA
   301  MARLQENGQK DVGSYQLPKG MSSHLNGQAR TSSSKLMASK SSATVFQNPM GIIPSSPKNA
   361  GYKNSLERNN IKQAANNSLL LHLLKSQTIP KPMNGHSHSE RGSIFEESST PTTIDEYSDN
   421  NPSFTDDSSG DESSYSNCVP IDLSCKHRTE KSESDQPVSL DNFTQSLLNT WDPKVPDVDI
   481  KEDQDTSKNS KLNSHQKVTL LQLLLGHKNE ENVEKNTSPQ GVHNDVSKFN TQNYARTSVI
   541  ESPSTNRTTP VSTPPLLTSS KAGSPINLSQ HSLVIKWNSP PYVCSTQSEK LTNTASNHSM
   601  DLTKSKDPPG EKPAQNEGAQ NSATFSASKL LQNLAQCGMQ SSMSVEEQRP SKQLLTGNTD
   661  KPIGMIDRLN SPLLSNKTNA VEENKAFSSQ PTGPEPGLSG SEIENLLERR TVLQLLLGNP
   721  NKGKSEKKEK TPLRDESTQE HSERALSEQI LMVKIKSEPC DDLQIPNTNV HLSHDAKSAP
   781  FLGMAPAVQR SAPALPVSED FKSEPVSPQD FSFSKNGLLS RLLRQNQDSY LADDSDRSHR
   841  NNEMALLESK NLCMVPKKRK LYTEPLENPF KKMKNNIVDA ANNHSAPEVL YGSLLNQEEL
   901  KFSRNDLEFK YPAGHGSASE SEHRSWARES KSFNVLKQLL LSENCVRDLS PHRSNSVADS
   961  KKKGHKNNVT NSKPEFSISS LNGLMYSSTQ PSSCMDNRTF SYPGVVKTPV SPTFPEHLGC
  1021  AGSRPESGLL NGCSMPSEKG PIKWVITDAE KNEYEKDSPR LTKTNPILYY MLQKGGNSVT
  1081  SRETQDKDIW REASSAESVS QVTAKEELLP TAETKASFFN LRSPYNSHMG NNASRPHSAN
  1141  GEVYGLLGSV LTIKKESE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

retina: 29 nTPM
adipose tissue: 29 nTPM
liver: 25 nTPM
bone marrow: 25 nTPM
cervix: 23 nTPM
tongue: 22 nTPM

Single-cell type

hematopoietic stem cells: 746 nCPM
microglia: 653 nCPM
megakaryocyte progenitors: 478 nCPM
adipocytes: 330 nCPM
endometrial glandular cells: 296 nCPM
pituicytes/fscs: 244 nCPM

Immune cell

MAIT T-cell: 1.8 nTPM
naive B-cell: 1 nTPM
myeloid DC: 0.6 nTPM
plasmacytoid DC: 0.6 nTPM
naive CD4 T-cell: 0.5 nTPM
NK-cell: 0.5 nTPM

Brain region

cerebellum: 44 nTPM
white matter: 31 nTPM
hypothalamus: 30 nTPM
thalamus: 28 nTPM
cerebral cortex: 27 nTPM
choroid plexus: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NRIP1.

Disease | AllUniProt

Conditions NRIP1 is implicated in, by any mechanism.

Congenital anomalies of kidney and urinary tract 3 (CAKUT3) MIM:618270

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 357 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Congenital anomalies of kidney and urinary tract 3
Congenital anomaly of kidney and urinary tract

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: -0.46
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear receptor-interacting protein 1
Nuclear receptor-interacting protein 1, repression domain 1
Nuclear receptor-interacting protein 1, repression domain 2
Nuclear receptor-interacting protein 1, repression domain 3
Nuclear receptor-interacting protein 1, repression domain 4
Nuclear receptor-interacting protein 1 repression 1
Nuclear receptor-interacting protein 1 repression 2
Nuclear receptor-interacting protein 1 repression 3
Nuclear receptor-interacting protein 1 repression 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRIP1 as an antibody target. Whether an autoantibody or antibody against NRIP1 could matter depends on whether native NRIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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