Seroatlas · Human Serome Atlas

PIAS2

E3 SUMO-protein ligase PIAS2

Also known as: ARIP3, miz, PIAS2_HUMAN, PIASX-ALPHA, PIASX-BETA, ZMIZ4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75928
Gene: PIAS2
Ensembl: ENSG00000078043
Chromosome: 18
Canonical length: 621 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>O75928|PIAS2
     1  MADFEELRNM VSSFRVSELQ VLLGFAGRNK SGRKHDLLMR ALHLLKSGCS PAVQIKIREL
    61  YRRRYPRTLE GLSDLSTIKS SVFSLDGGSS PVEPDLAVAG IHSLPSTSVT PHSPSSPVGS
   121  VLLQDTKPTF EMQQPSPPIP PVHPDVQLKN LPFYDVLDVL IKPTSLVQSS IQRFQEKFFI
   181  FALTPQQVRE ICISRDFLPG GRRDYTVQVQ LRLCLAETSC PQEDNYPNSL CIKVNGKLFP
   241  LPGYAPPPKN GIEQKRPGRP LNITSLVRLS SAVPNQISIS WASEIGKNYS MSVYLVRQLT
   301  SAMLLQRLKM KGIRNPDHSR ALIKEKLTAD PDSEIATTSL RVSLMCPLGK MRLTIPCRAV
   361  TCTHLQCFDA ALYLQMNEKK PTWICPVCDK KAAYESLILD GLFMEILNDC SDVDEIKFQE
   421  DGSWCPMRPK KEAMKVSSQP CTKIESSSVL SKPCSVTVAS EASKKKVDVI DLTIESSSDE
   481  EEDPPAKRKC IFMSETQSSP TKGVLMYQPS SVRVPSVTSV DPAAIPPSLT DYSVPFHHTP
   541  ISSMSSDLPG LDFLSLIPVD PQYCPPMFLD SLTSPLTASS TSVTTTSSHE SSTHVSSSSS
   601  RSETGVITSS GSNIPDIISL D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

testis: 63 nTPM
skeletal muscle: 15 nTPM
cerebellum: 13 nTPM
parathyroid gland: 11 nTPM
retina: 10 nTPM
tongue: 9.5 nTPM

Single-cell type

late spermatids: 800 nCPM
late primary spermatocytes: 548 nCPM
early spermatids: 534 nCPM
neutrophils: 255 nCPM
cardiomyocytes: 224 nCPM
myonuclei: 213 nCPM

Immune cell

naive B-cell: 3 nTPM
naive CD4 T-cell: 2.5 nTPM
memory CD8 T-cell: 2.3 nTPM
naive CD8 T-cell: 2.1 nTPM
plasmacytoid DC: 2.1 nTPM
gdT-cell: 2 nTPM

Brain region

cerebellum: 57 nTPM
cerebral cortex: 42 nTPM
hypothalamus: 39 nTPM
basal ganglia: 38 nTPM
white matter: 38 nTPM
hippocampal formation: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIAS2.

Disease | ImmuneIEDB

Conditions an epitope on PIAS2 was assayed in.

breast cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 2.06
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIAS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIAS2 as an antibody target. Whether an autoantibody or antibody against PIAS2 could matter depends on whether native PIAS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIAS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIAS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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