Seroatlas · Human Serome Atlas

PIAS1

E3 SUMO-protein ligase PIAS1

Also known as: DDXBP1, GBP, GU/RH-II, PIAS1_HUMAN, ZMIZ3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75925
Gene: PIAS1
Ensembl: ENSG00000033800
Chromosome: 15
Canonical length: 651 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

651 residues, UniProt reviewed canonical sequence.

>O75925|PIAS1
     1  MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS PAVQMKIKEL
    61  YRRRFPQKIM TPADLSIPNV HSSPMPATLS PSTIPQLTYD GHPASSPLLP VSLLGPKHEL
   121  ELPHLTSALH PVHPDIKLQK LPFYDLLDEL IKPTSLASDN SQRFRETCFA FALTPQQVQQ
   181  ISSSMDISGT KCDFTVQVQL RFCLSETSCP QEDHFPPNLC VKVNTKPCSL PGYLPPTKNG
   241  VEPKRPSRPI NITSLVRLST TVPNTIVVSW TAEIGRNYSM AVYLVKQLSS TVLLQRLRAK
   301  GIRNPDHSRA LIKEKLTADP DSEIATTSLR VSLLCPLGKM RLTIPCRALT CSHLQCFDAT
   361  LYIQMNEKKP TWVCPVCDKK APYEHLIIDG LFMEILKYCT DCDEIQFKED GTWAPMRSKK
   421  EVQEVSASYN GVDGCLSSTL EHQVASHHQS SNKNKKVEVI DLTIDSSSDE EEEEPSAKRT
   481  CPSLSPTSPL NNKGILSLPH QASPVSRTPS LPAVDTSYIN TSLIQDYRHP FHMTPMPYDL
   541  QGLDFFPFLS GDNQHYNTSL LAAAAAAVSD DQDLLHSSRF FPYTSSQMFL DQLSAGGSTS
   601  LPTTNGSSSG SNSSLVSSNS LRESHSHTVT NRSSTDTASI FGIIPDIISL D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIAS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thymus: 23 nTPM
bone marrow: 22 nTPM
retina: 20 nTPM
testis: 19 nTPM
thyroid gland: 18 nTPM
ovary: 18 nTPM

Single-cell type

neutrophils: 1,663 nCPM
neutrophil progenitors: 1,313 nCPM
leydig cells: 625 nCPM
microglia: 555 nCPM
kupffer cells: 498 nCPM
esophageal apical cells: 454 nCPM

Immune cell

neutrophil: 71 nTPM
eosinophil: 42 nTPM
basophil: 34 nTPM
classical monocyte: 31 nTPM
myeloid DC: 31 nTPM
total PBMC: 27 nTPM

Brain region

cerebellum: 36 nTPM
cerebral cortex: 30 nTPM
hypothalamus: 29 nTPM
basal ganglia: 26 nTPM
white matter: 26 nTPM
choroid plexus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIAS1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Nephronophthisis

Disease | ImmuneIEDB

Conditions an epitope on PIAS1 was assayed in.

breast cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.09
gnomAD pLI: 1
gnomAD missense Z: 2.72
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIAS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIAS1 as an antibody target. Whether an autoantibody or antibody against PIAS1 could matter depends on whether native PIAS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIAS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIAS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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