Seroatlas · Human Serome Atlas

FOSL1

Fos-related antigen 1

Also known as: FOSL1_HUMAN, fra-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15407
Gene
FOSL1
Ensembl
ENSG00000175592
Chromosome
11
Canonical length
271 aa
Protein class
Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>P15407|FOSL1
     1  MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG
    61  PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA
   121  KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE
   181  GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST
   241  PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 78 nTPM
  • adipose tissue: 51 nTPM
  • esophagus: 46 nTPM
  • gallbladder: 28 nTPM
  • bone marrow: 25 nTPM
  • skin: 24 nTPM

Single-cell type

  • esophageal apical cells: 713 nCPM
  • suprabasal keratinocytes: 693 nCPM
  • esophageal suprabasal cells: 568 nCPM
  • basal keratinocytes: 527 nCPM
  • ocular epithelial cells: 468 nCPM
  • urothelial cells: 462 nCPM

Immune cell

  • myeloid DC: 3.4 nTPM
  • classical monocyte: 0.8 nTPM
  • intermediate monocyte: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • total PBMC: 0.5 nTPM
  • plasmacytoid DC: 0.4 nTPM

Brain region

  • cerebral cortex: 9.2 nTPM
  • cerebellum: 5.2 nTPM
  • pons: 5.2 nTPM
  • thalamus: 5 nTPM
  • medulla oblongata: 4.6 nTPM
  • hypothalamus: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0.16
gnomAD missense Z
0.4
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOSL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOSL1 as an antibody target. Whether an autoantibody or antibody against FOSL1 could matter depends on whether native FOSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOSL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOSL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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