Seroatlas · Human Serome Atlas

FOSL2

Fos-related antigen 2

Also known as: FLJ23306, FOSL2_HUMAN, FRA2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15408
Gene
FOSL2
Ensembl
ENSG00000075426
Chromosome
2
Canonical length
326 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>P15408|FOSL2
     1  MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL
    61  QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS
   121  PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL
   181  EFMLVAHGPV CKISPEERRS PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK
   241  AQRSVIKPIS IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC
   301  SKAHRRSSSS GDQSSDSLNS PTLLAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOSL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
219 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 219 nTPM
  • adrenal gland: 160 nTPM
  • blood vessel: 153 nTPM
  • adipose tissue: 140 nTPM
  • ovary: 124 nTPM
  • esophagus: 124 nTPM

Single-cell type

  • neutrophils: 697 nCPM
  • monocytes: 475 nCPM
  • esophageal apical cells: 455 nCPM
  • adrenal cortex cells: 430 nCPM
  • mast cells: 381 nCPM
  • prostatic hillock cells: 297 nCPM

Immune cell

  • neutrophil: 37 nTPM
  • basophil: 17 nTPM
  • classical monocyte: 9.9 nTPM
  • eosinophil: 8.8 nTPM
  • gdT-cell: 7.7 nTPM
  • intermediate monocyte: 7.4 nTPM

Brain region

  • medulla oblongata: 72 nTPM
  • hippocampal formation: 69 nTPM
  • hypothalamus: 66 nTPM
  • cerebral cortex: 64 nTPM
  • thalamus: 47 nTPM
  • midbrain: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOSL2.

Disease | AllUniProt

Conditions FOSL2 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.98
gnomAD missense Z
1.6
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOSL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOSL2 as an antibody target. Whether an autoantibody or antibody against FOSL2 could matter depends on whether native FOSL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOSL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOSL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOSL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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