Seroatlas · Human Serome Atlas

HSP90AA1

Heat shock protein HSP 90-alpha

Also known as: FLJ31884, HS90A_HUMAN, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07900
Gene
HSP90AA1
Ensembl
ENSG00000080824
Chromosome
14
Canonical length
732 aa
Protein class
Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

732 residues, UniProt reviewed canonical sequence.

>P07900|HSP90AA1
     1  MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIR
    61  YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME
   121  ALQAGADISM IGQFGVGFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGEPM
   181  GRGTKVILHL KEDQTEYLEE RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED
   241  KEEEKEKEEK ESEDKPEIED VGSDEEEEKK DGDKKKKKKI KEKYIDQEEL NKTKPIWTRN
   301  PDDITNEEYG EFYKSLTNDW EDHLAVKHFS VEGQLEFRAL LFVPRRAPFD LFENRKKKNN
   361  IKLYVRRVFI MDNCEELIPE YLNFIRGVVD SEDLPLNISR EMLQQSKILK VIRKNLVKKC
   421  LELFTELAED KENYKKFYEQ FSKNIKLGIH EDSQNRKKLS ELLRYYTSAS GDEMVSLKDY
   481  CTRMKENQKH IYYITGETKD QVANSAFVER LRKHGLEVIY MIEPIDEYCV QQLKEFEGKT
   541  LVSVTKEGLE LPEDEEEKKK QEEKKTKFEN LCKIMKDILE KKVEKVVVSN RLVTSPCCIV
   601  TSTYGWTANM ERIMKAQALR DNSTMGYMAA KKHLEINPDH SIIETLRQKA EADKNDKSVK
   661  DLVILLYETA LLSSGFSLED PQTHANRIYR MIKLGLGIDE DDPTADDTSA AVTEEMPPLE
   721  GDDDTSRMEE VD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSP90AA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
1,045 nTPM

Expression across tissuesHPA

Tissue

  • retina: 1,045 nTPM
  • choroid plexus: 897 nTPM
  • midbrain: 697 nTPM
  • spinal cord: 655 nTPM
  • hypothalamus: 635 nTPM
  • cerebral cortex: 618 nTPM

Single-cell type

  • pancreatic duct cells: 6,948 nCPM
  • epididymal efferent duct absorptive cells: 6,812 nCPM
  • epididymal efferent duct ciliated cells: 5,149 nCPM
  • respiratory ciliated cells: 5,132 nCPM
  • late primary spermatocytes: 4,424 nCPM
  • fallopian tube ciliated cells: 3,905 nCPM

Immune cell

  • MAIT T-cell: 256 nTPM
  • NK-cell: 254 nTPM
  • plasmacytoid DC: 209 nTPM
  • memory CD8 T-cell: 202 nTPM
  • gdT-cell: 196 nTPM
  • basophil: 186 nTPM

Brain region

  • white matter: 1,559 nTPM
  • pons: 1,023 nTPM
  • hypothalamus: 979 nTPM
  • midbrain: 961 nTPM
  • cerebral cortex: 942 nTPM
  • medulla oblongata: 881 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSP90AA1.

Disease | ImmuneIEDB

Conditions an epitope on HSP90AA1 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against HSP90AA1 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for HSP90AA1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

29 publications

Show 20 more of 29 total

Reference: B cellIEDB

4 publications

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.86
gnomAD missense Z
1.04
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSP90AA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSP90AA1 as an antibody target. Whether an autoantibody or antibody against HSP90AA1 could matter depends on whether native HSP90AA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSP90AA1 is annotated at the cell surface, where native HSP90AA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HSP90AA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSP90AA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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