Seroatlas · Human Serome Atlas

GOPC

Golgi-associated PDZ and coiled-coil motif-containing protein

Also known as: CAL, dJ94G16.2, FIG, GOPC_HUMAN, GOPC1, PIST

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HD26
Gene
GOPC
Ensembl
ENSG00000047932
Chromosome
6
Canonical length
462 aa
Protein class
Cancer-related genes, Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Golgi apparatus,Calyx,Connecting piece,Mid piece,Principal piece
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q9HD26|GOPC
     1  MSAGGPCPAA AGGGPGGASC SVGAPGGVSM FRWLEVLEKE FDKAFVDVDL LLGEIDPDQA
    61  DITYEGRQKM TSLSSCFAQL CHKAQSVSQI NHKLEAQLVD LKSELTETQA EKVVLEKEVH
   121  DQLLQLHSIQ LQLHAKTGQS ADSGTIKAKL SGPSVEELER ELEANKKEKM KEAQLEAEVK
   181  LLRKENEALR RHIAVLQAEV YGARLAAKYL DKELAGRVQQ IQLLGRDMKG PAHDKLWNQL
   241  EAEIHLHRHK TVIRACRGRN DLKRPMQAPP GHDQDSLKKS QGVGPIRKVL LLKEDHEGLG
   301  ISITGGKEHG VPILISEIHP GQPADRCGGL HVGDAILAVN GVNLRDTKHK EAVTILSQQR
   361  GEIEFEVVYV APEVDSDDEN VEYEDESGHR YRLYLDELEG GGNPGASCKD TSGEIKVLQG
   421  FNKKAVTDTH ENGDLGTASE TPLDDGASKL DDLHTLYHKK SY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 22 nTPM
  • cervix: 22 nTPM
  • endometrium: 22 nTPM
  • ovary: 21 nTPM
  • parathyroid gland: 21 nTPM
  • heart muscle: 21 nTPM

Single-cell type

  • early primary spermatocytes: 101 nCPM
  • retinal horizontal cells: 94 nCPM
  • gonadotrophs: 88 nCPM
  • lactotrophs: 86 nCPM
  • cytotrophoblasts: 86 nCPM
  • somatotrophs: 79 nCPM

Immune cell

  • basophil: 11 nTPM
  • MAIT T-cell: 9.3 nTPM
  • plasmacytoid DC: 9.3 nTPM
  • NK-cell: 9.2 nTPM
  • naive CD8 T-cell: 8.5 nTPM
  • naive CD4 T-cell: 8.2 nTPM

Brain region

  • white matter: 27 nTPM
  • cerebral cortex: 26 nTPM
  • cerebellum: 25 nTPM
  • basal ganglia: 23 nTPM
  • spinal cord: 21 nTPM
  • hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.88
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOPC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOPC as an antibody target. Whether an autoantibody or antibody against GOPC could matter depends on whether native GOPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOPC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GOPC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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