Seroatlas · Human Serome Atlas

PAGE4

P antigen family member 4

Also known as: CT16.7, GAGEC1, PAGE-4, PAGE4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60829
Gene
PAGE4
Ensembl
ENSG00000101951
Chromosome
X
Canonical length
102 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>O60829|PAGE4
     1  MSARVRSRSR GRGDGQEAPD VVAFVAPGES QQEEPPTDNQ DIEPGQEREG TPPIEERKVE
    61  GDCQEMDLEK TRSERGDGSD VKEKTPPNPK HAKTKEAGDG QP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAGE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
960 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 960 nTPM
  • epididymis: 822 nTPM
  • prostate: 152 nTPM
  • seminal vesicle: 72 nTPM
  • fallopian tube: 49 nTPM
  • endometrium: 48 nTPM

Single-cell type

  • cytotrophoblasts: 16,498 nCPM
  • syncytiotrophoblasts: 9,302 nCPM
  • migrating cytotrophoblasts: 8,434 nCPM
  • fibroblasts: 216 nCPM
  • hofbauer cells: 198 nCPM
  • extravillous trophoblasts: 169 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • hypothalamus: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • choroid plexus: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM
  • thalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0.69
gnomAD missense Z
0.08
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAGE4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAGE4 as an antibody target. Whether an autoantibody or antibody against PAGE4 could matter depends on whether native PAGE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAGE4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAGE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAGE4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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