Seroatlas · Human Serome Atlas

FOS

Protein c-Fos

Also known as: AP-1, c-fos, FOS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01100
Gene
FOS
Ensembl
ENSG00000170345
Chromosome
14
Canonical length
380 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>P01100|FOS
     1  MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF
    61  IPTVTAISTS PDLQWLVQPA LVSSVAPSQT RAPHPFGVPA PSAGAYSRAG VVKTMTGGRA
   121  QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ
   181  TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEV ATPESEEAFT
   241  LPLLNDPEPK PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA
   301  ADWEPLHSGS LGMGPMATEL EPLCTPVVTC TPSCTAYTSS FVFTYPEADS FPSCAAAHRK
   361  GSSSNEPSSD SLSSPTLLAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
2,146 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 2,146 nTPM
  • skin: 1,567 nTPM
  • esophagus: 1,178 nTPM
  • ovary: 1,091 nTPM
  • gallbladder: 1,088 nTPM
  • fallopian tube: 1,084 nTPM

Single-cell type

  • neutrophils: 6,882 nCPM
  • decidual stromal cells: 6,299 nCPM
  • endometrial luminal cells: 6,203 nCPM
  • ovarian stromal cells: 5,794 nCPM
  • breast secretory cells: 4,280 nCPM
  • smooth muscle cells: 4,047 nCPM

Immune cell

  • neutrophil: 507 nTPM
  • eosinophil: 90 nTPM
  • classical monocyte: 81 nTPM
  • myeloid DC: 70 nTPM
  • basophil: 38 nTPM
  • total PBMC: 28 nTPM

Brain region

  • hypothalamus: 367 nTPM
  • cerebellum: 333 nTPM
  • medulla oblongata: 264 nTPM
  • white matter: 205 nTPM
  • choroid plexus: 195 nTPM
  • cerebral cortex: 190 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOS.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.26
gnomAD missense Z
1.08
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOS as an antibody target. Whether an autoantibody or antibody against FOS could matter depends on whether native FOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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