Seroatlas · Human Serome Atlas

CREB5

Cyclic AMP-responsive element-binding protein 5

Also known as: CRE-BPA, CREB5_HUMAN, H_GS165L15.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02930
Gene: CREB5
Ensembl: ENSG00000146592
Chromosome: 7
Canonical length: 508 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q02930|CREB5
     1  MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK TDNMLSDQTP
    61  TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS MHNAVGGAMT GPGTHQLSSA
   121  RLPNHDTNVV IQQAMPSPQS SSVITQAPST NRQIGPVPGS LSSLLHLHNR QRQPMPASMP
   181  GTLPNPTMPG SSAVLMPMER QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL
   241  THHPAAMSNG NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH
   301  PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM QPTQTIQPPQ
   361  PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV MSLEKKAEEL TQTNMQLQNE
   421  VSMLKNEVAQ LKQLLLTHKD CPITAMQKES QGYLSPESSP PASPVPACSQ QQVIQHNTIT
   481  TSSSVSEVVG SSTLSQLTTH RTDLNPIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 11 nTPM
adipose tissue: 9.9 nTPM
hippocampal formation: 8.5 nTPM
cerebral cortex: 7.9 nTPM
endometrium: 7.8 nTPM
spinal cord: 7.6 nTPM

Single-cell type

neutrophils: 2,649 nCPM
pancreatic duct cells: 1,172 nCPM
oligodendrocytes: 879 nCPM
fibro-adipogenic progenitors: 504 nCPM
schwann cells: 495 nCPM
myosatellite cells: 395 nCPM

Immune cell

neutrophil: 200 nTPM
classical monocyte: 30 nTPM
myeloid DC: 18 nTPM
intermediate monocyte: 9.7 nTPM
total PBMC: 7 nTPM
non-classical monocyte: 3.9 nTPM

Brain region

white matter: 94 nTPM
thalamus: 70 nTPM
medulla oblongata: 64 nTPM
basal ganglia: 64 nTPM
hypothalamus: 62 nTPM
cerebral cortex: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.22
gnomAD missense Z: 1.61
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CREB5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CREB5 as an antibody target. Whether an autoantibody or antibody against CREB5 could matter depends on whether native CREB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CREB5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CREB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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