Seroatlas · Human Serome Atlas

BATF3

Basic leucine zipper transcriptional factor ATF-like 3

Also known as: BATF3_HUMAN, JDP1, JUNDM1, SNFT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NR55
Gene: BATF3
Ensembl: ENSG00000123685
Chromosome: 1
Canonical length: 127 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>Q9NR55|BATF3
     1  MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ RSRKKQTQKA
    61  DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK MCPLLLCPMN FVPVPPRPDP
   121  VAGCLPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BATF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 25 nTPM
spleen: 11 nTPM
basal ganglia: 10 nTPM
lung: 8.8 nTPM
adipose tissue: 8.5 nTPM
cerebral cortex: 6.3 nTPM

Single-cell type

cdc: 74 nCPM
extravillous trophoblasts: 58 nCPM
microglia: 26 nCPM
pericytes: 25 nCPM
macrophages: 19 nCPM
vascular smooth muscle cells: 19 nCPM

Immune cell

non-classical monocyte: 100 nTPM
intermediate monocyte: 66 nTPM
myeloid DC: 55 nTPM
classical monocyte: 14 nTPM
total PBMC: 8.8 nTPM
neutrophil: 2.2 nTPM

Brain region

choroid plexus: 17 nTPM
basal ganglia: 4.2 nTPM
cerebral cortex: 3.2 nTPM
spinal cord: 3 nTPM
hippocampal formation: 2.5 nTPM
white matter: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0.03
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BATF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BATF3 as an antibody target. Whether an autoantibody or antibody against BATF3 could matter depends on whether native BATF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BATF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BATF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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