Seroatlas · Human Serome Atlas

FOSB

Protein FosB

Also known as: AP-1, DKFZp686C0818, FOSB_HUMAN, G0S3, GOS3, GOSB, MGC42291

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53539
Gene
FOSB
Ensembl
ENSG00000125740
Chromosome
19
Canonical length
338 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>P53539|FOSB
     1  MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA
    61  ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS
   121  GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT
   181  DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD
   241  LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY
   301  TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOSB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
410 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 410 nTPM
  • adipose tissue: 370 nTPM
  • smooth muscle: 331 nTPM
  • gallbladder: 325 nTPM
  • thyroid gland: 297 nTPM
  • skin: 259 nTPM

Single-cell type

  • breast secretory cells: 2,187 nCPM
  • endometrial luminal cells: 1,976 nCPM
  • mast cells: 1,960 nCPM
  • salivary myoepithelial cells: 1,717 nCPM
  • breast hormone-responsive cells: 1,692 nCPM
  • endometrial glandular cells: 1,465 nCPM

Immune cell

  • neutrophil: 4.6 nTPM
  • classical monocyte: 1.2 nTPM
  • eosinophil: 1 nTPM
  • myeloid DC: 1 nTPM
  • basophil: 0.9 nTPM
  • MAIT T-cell: 0.4 nTPM

Brain region

  • cerebral cortex: 90 nTPM
  • cerebellum: 70 nTPM
  • hippocampal formation: 27 nTPM
  • hypothalamus: 19 nTPM
  • basal ganglia: 15 nTPM
  • choroid plexus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
1.55
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOSB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOSB as an antibody target. Whether an autoantibody or antibody against FOSB could matter depends on whether native FOSB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOSB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOSB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOSB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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