Seroatlas · Human Serome Atlas

TSC22D3

TSC22 domain family protein 3

Also known as: DIP, DSIPI, GILZ, hDIP, T22D3_HUMAN, TSC-22R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99576
Gene: TSC22D3
Ensembl: ENSG00000157514
Chromosome: X
Canonical length: 134 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Golgi apparatus,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q99576|TSC22D3
     1  MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAI DNKIEQAMDL
    61  VKNHLMYAVR EEVEILKEQI RELVEKNSQL ERENTLLKTL ASPEQLEKFQ SCLSPEEPAP
   121  ESPQVPEAPG GSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSC22D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 1,025 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 1,025 nTPM
skeletal muscle: 692 nTPM
urinary bladder: 520 nTPM
adipose tissue: 511 nTPM
lung: 492 nTPM
skin: 465 nTPM

Single-cell type

neutrophils: 1,719 nCPM
mast cells: 1,534 nCPM
platelets: 1,434 nCPM
innate lymphoid cells: 1,242 nCPM
plasma cells: 1,190 nCPM
t-cells: 1,108 nCPM

Immune cell

neutrophil: 2,405 nTPM
eosinophil: 1,657 nTPM
total PBMC: 1,623 nTPM
T-reg: 1,084 nTPM
NK-cell: 970 nTPM
non-classical monocyte: 856 nTPM

Brain region

choroid plexus: 121 nTPM
hypothalamus: 121 nTPM
cerebellum: 113 nTPM
thalamus: 113 nTPM
pons: 111 nTPM
cerebral cortex: 109 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.43
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSC22D3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSC22D3 as an antibody target. Whether an autoantibody or antibody against TSC22D3 could matter depends on whether native TSC22D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSC22D3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSC22D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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