Seroatlas · Human Serome Atlas

DNAJC7

DnaJ homolog subfamily C member 7

Also known as: DNJC7_HUMAN, TPR2, TTC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99615
Gene
DNAJC7
Ensembl
ENSG00000168259
Chromosome
17
Canonical length
494 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>Q99615|DNAJC7
     1  MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK
    61  NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ
   121  RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI
   181  LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA
   241  PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR
   301  GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT
   361  KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV
   421  QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS
   481  FEASGPGNFF FQFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 112 nTPM
  • skeletal muscle: 103 nTPM
  • cerebral cortex: 101 nTPM
  • basal ganglia: 99 nTPM
  • amygdala: 84 nTPM
  • heart muscle: 84 nTPM

Single-cell type

  • esophageal apical cells: 282 nCPM
  • esophageal suprabasal cells: 205 nCPM
  • pdcs: 180 nCPM
  • syncytiotrophoblasts: 179 nCPM
  • monocytes: 172 nCPM
  • esophageal basal cells: 162 nCPM

Immune cell

  • plasmacytoid DC: 99 nTPM
  • non-classical monocyte: 60 nTPM
  • intermediate monocyte: 58 nTPM
  • myeloid DC: 58 nTPM
  • classical monocyte: 56 nTPM
  • basophil: 50 nTPM

Brain region

  • cerebral cortex: 55 nTPM
  • hypothalamus: 53 nTPM
  • medulla oblongata: 51 nTPM
  • pons: 50 nTPM
  • white matter: 50 nTPM
  • midbrain: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.51
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC7 as an antibody target. Whether an autoantibody or antibody against DNAJC7 could matter depends on whether native DNAJC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAJC7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...