Seroatlas · Human Serome Atlas

ZMYND10

Zinc finger MYND domain-containing protein 10

Also known as: BLU, CILD22, DNAAF7, ZMY10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75800
Gene
ZMYND10
Ensembl
ENSG00000004838
Chromosome
3
Canonical length
440 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>O75800|ZMYND10
     1  MGDLELLLPG EAEVLVRGLR SFPLREMGSE GWNQQHENLE KLNMQAILDA TVSQGEPIQE
    61  LLVTHGKVPT LVEELIAVEM WKQKVFPVFC RVEDFKPQNT FPIYMVVHHE ASIINLLETV
   121  FFHKEVCESA EDTVLDLVDY CHRKLTLLVA QSGCGGPPEG EGSQDSNPMQ ELQKQAELME
   181  FEIALKALSV LRYITDCVDS LSLSTLSRML STHNLPCLLV ELLEHSPWSR REGGKLQQFE
   241  GSRWHTVAPS EQQKLSKLDG QVWIALYNLL LSPEAQARYC LTSFAKGRLL KLRAFLTDTL
   301  LDQLPNLAHL QSFLAHLTLT ETQPPKKDLV LEQIPEIWER LERENRGKWQ AIAKHQLQHV
   361  FSPSEQDLRL QARRWAETYR LDVLEAVAPE RPRCAYCSAE ASKRCSRCQN EWYCCRECQV
   421  KHWEKHGKTC VLAAQGDRAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYND10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
227 nTPM

Expression across tissuesHPA

Tissue

  • testis: 227 nTPM
  • fallopian tube: 113 nTPM
  • choroid plexus: 80 nTPM
  • basal ganglia: 11 nTPM
  • lung: 11 nTPM
  • hypothalamus: 9.7 nTPM

Single-cell type

  • late primary spermatocytes: 1,156 nCPM
  • late spermatids: 650 nCPM
  • respiratory ciliated cells: 611 nCPM
  • fallopian tube ciliated cells: 607 nCPM
  • epididymal efferent duct ciliated cells: 465 nCPM
  • endometrial ciliated cells: 259 nCPM

Immune cell

  • NK-cell: 1.2 nTPM
  • gdT-cell: 0.6 nTPM
  • MAIT T-cell: 0.2 nTPM
  • myeloid DC: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • choroid plexus: 58 nTPM
  • midbrain: 31 nTPM
  • medulla oblongata: 25 nTPM
  • spinal cord: 19 nTPM
  • white matter: 16 nTPM
  • hypothalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZMYND10.

Disease | AllUniProt

Conditions ZMYND10 is implicated in, by any mechanism.

  • Ciliary dyskinesia, primary, 22 (CILD22) MIM:615444

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 300 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.93
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYND10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYND10 as an antibody target. Whether an autoantibody or antibody against ZMYND10 could matter depends on whether native ZMYND10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYND10 is annotated at the cell surface, where native ZMYND10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZMYND10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZMYND10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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