Seroatlas · Human Serome Atlas

BAG5

BAG family molecular chaperone regulator 5

Also known as: BAG5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL15
Gene: BAG5
Ensembl: ENSG00000166170
Chromosome: 14
Canonical length: 447 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q9UL15|BAG5
     1  MDMGNQHPSI SRLQEIQKEV KSVEQQVIGF SGLSDDKNYK KLERILTKQL FEIDSVDTEG
    61  KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFEE AQSLVREKIV PFYNGGNCVT
   121  DEFEEGIQDI ILRLTHVKTG GKISLRKARY HTLTKICAVQ EIIEDCMKKQ PSLPLSEDAH
   181  PSVAKINFVM CEVNKARGVL IALLMGVNNN ETCRHLSCVL SGLIADLDAL DVCGRTEIRN
   241  YRREVVEDIN KLLKYLDLEE EADTTKAFDL RQNHSILKIE KVLKRMREIK NELLQAQNPS
   301  ELYLSSKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYIDLKE ALEKRKLFAC
   361  EEHPSHKAVW NVLGNLSEIQ GEVLSFDGNR TDKNYIRLEE LLTKQLLALD AVDPQGEEKC
   421  KAARKQAVRL AQNILSYLDL KSDEWEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

testis: 119 nTPM
bone marrow: 26 nTPM
adipose tissue: 23 nTPM
thyroid gland: 22 nTPM
esophagus: 21 nTPM
skin: 19 nTPM

Single-cell type

late spermatids: 2,666 nCPM
early spermatids: 1,915 nCPM
late primary spermatocytes: 639 nCPM
suprabasal keratinocytes: 96 nCPM
endometrial luminal cells: 92 nCPM
esophageal apical cells: 78 nCPM

Immune cell

basophil: 29 nTPM
non-classical monocyte: 22 nTPM
intermediate monocyte: 15 nTPM
myeloid DC: 14 nTPM
classical monocyte: 13 nTPM
NK-cell: 13 nTPM

Brain region

cerebellum: 30 nTPM
choroid plexus: 29 nTPM
cerebral cortex: 26 nTPM
white matter: 26 nTPM
hypothalamus: 24 nTPM
basal ganglia: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BAG5.

Disease | AllUniProt

Conditions BAG5 is implicated in, by any mechanism.

Cardiomyopathy, dilated, 2F (CMD2F) MIM:619747

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 85 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiomyopathy, dilated, 2F
Cardiomyopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAG5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAG5 as an antibody target. Whether an autoantibody or antibody against BAG5 could matter depends on whether native BAG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAG5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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