BAG2
BAG family molecular chaperone regulator 2
Also known as: BAG2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95816
- Gene
- BAG2
- Ensembl
- ENSG00000112208
- Chromosome
- 6
- Canonical length
- 211 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol,Mid piece,Principal piece
OverviewNCBI Gene
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
211 residues, UniProt reviewed canonical sequence.
>O95816|BAG2
1 MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI
61 HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV
121 VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN
181 IENSDKAIKL LEHSKGAGSK TLQQNAESRF NLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BAG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- colon: 30 nTPM
- smooth muscle: 27 nTPM
- endometrium: 21 nTPM
- urinary bladder: 18 nTPM
- blood vessel: 16 nTPM
- seminal vesicle: 15 nTPM
Single-cell type
- late primary spermatocytes: 276 nCPM
- smooth muscle cells: 203 nCPM
- decidual stromal cells: 154 nCPM
- early spermatids: 129 nCPM
- cytotrophoblasts: 101 nCPM
- oocytes: 92 nCPM
Immune cell
- memory B-cell: 3.5 nTPM
- naive CD4 T-cell: 3.4 nTPM
- naive B-cell: 3 nTPM
- naive CD8 T-cell: 2.9 nTPM
- MAIT T-cell: 2.2 nTPM
- NK-cell: 2.1 nTPM
Brain region
- choroid plexus: 5.4 nTPM
- white matter: 5 nTPM
- cerebellum: 4.9 nTPM
- midbrain: 4.9 nTPM
- hypothalamus: 4.8 nTPM
- basal ganglia: 4.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.15
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.28
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of protein ubiquitination
- positive regulation of proteasomal protein catabolic process
- positive regulation of protein processing
- protein folding
- protein metabolic process
- protein stabilization
Molecular functions
- adenyl-nucleotide exchange factor activity
- heat shock protein binding
- identical protein binding
- protein-folding chaperone binding
- tau protein binding
- transmembrane transporter binding
- ubiquitin protein ligase binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- BAG domain
- BAG family molecular chaperone regulator 2
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BAG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BAG2 as an antibody target. Whether an autoantibody or antibody against BAG2 could matter depends on whether native BAG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BAG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BAG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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