Seroatlas · Human Serome Atlas

HOPX

Homeodomain-only protein

Also known as: HOP, HOP_HUMAN, LAGY, NECC1, OB1, SMAP31

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BPY8
Gene: HOPX
Ensembl: ENSG00000171476
Chromosome: 4
Canonical length: 73 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

73 residues, UniProt reviewed canonical sequence.

>Q9BPY8|HOPX
     1  MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR
    61  SEGLPSECRS VTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOPX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 1,402 nTPM

Expression across tissuesHPA

Tissue

skin: 1,402 nTPM
esophagus: 712 nTPM
epididymis: 511 nTPM
lung: 361 nTPM
vagina: 355 nTPM
cerebral cortex: 299 nTPM

Single-cell type

esophageal apical cells: 29,334 nCPM
alveolar cells type 1: 2,857 nCPM
alveolar cells type 2: 2,685 nCPM
transitional alveolar cells: 1,952 nCPM
epididymal principal cells: 1,923 nCPM
suprabasal keratinocytes: 1,063 nCPM

Immune cell

NK-cell: 784 nTPM
gdT-cell: 519 nTPM
total PBMC: 366 nTPM
MAIT T-cell: 283 nTPM
memory CD8 T-cell: 228 nTPM
naive CD8 T-cell: 151 nTPM

Brain region

cerebral cortex: 133 nTPM
spinal cord: 107 nTPM
choroid plexus: 107 nTPM
medulla oblongata: 105 nTPM
basal ganglia: 98 nTPM
white matter: 95 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HOPX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOPX as an antibody target. Whether an autoantibody or antibody against HOPX could matter depends on whether native HOPX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOPX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOPX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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