Seroatlas · Human Serome Atlas

CITED1

Cbp/p300-interacting transactivator 1

Also known as: CITE1_HUMAN, MSG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99966
Gene: CITED1
Ensembl: ENSG00000125931
Chromosome: X
Canonical length: 193 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q99966|CITED1
     1  MPTTSRPALD VKGGTSPAKE DANQEMSSVA YSNLAVKDRK AVAILHYPGV ASNGTKASGA
    61  PTSSSGSPIG SPTTTPPTKP PSFNLHPAPH LLASMHLQKL NSQYQGMAAA TPGQPGEAGP
   121  LQNWDFGAQA GGAESLSPSA GAQSPAIIDS DPVDEEVLMS LVVELGLDRA NELPELWLGQ
   181  NEFDFTADFP SSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CITED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 1,389 nTPM

Expression across tissuesHPA

Tissue

epididymis: 1,389 nTPM
pituitary gland: 199 nTPM
testis: 192 nTPM
hypothalamus: 71 nTPM
breast: 22 nTPM
cerebral cortex: 14 nTPM

Single-cell type

epididymal principal cells: 1,936 nCPM
epididymal efferent duct absorptive cells: 168 nCPM
breast hormone-responsive cells: 37 nCPM
sertoli cells: 37 nCPM
melanocytes: 30 nCPM
other brain neurons: 23 nCPM

Immune cell

eosinophil: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 117 nTPM
pons: 46 nTPM
cerebral cortex: 27 nTPM
basal ganglia: 20 nTPM
thalamus: 13 nTPM
medulla oblongata: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0.02
gnomAD missense Z: 0.88
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CITED1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CITED1 as an antibody target. Whether an autoantibody or antibody against CITED1 could matter depends on whether native CITED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CITED1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CITED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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