Seroatlas · Human Serome Atlas

DNAJC9

DnaJ homolog subfamily C member 9

Also known as: DNJC9_HUMAN, JDD1, SB73

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXX5
Gene: DNAJC9
Ensembl: ENSG00000213551
Chromosome: 10
Canonical length: 260 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables heat shock protein binding activity; histone binding activity; and protein-folding chaperone binding activity. Involved in nucleosome assembly and positive regulation of ATP-dependent activity. Located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q8WXX5|DNAJC9
     1  MGLLDLCEEV FGTADLYRVL GVRREASDGE VRRGYHKVSL QVHPDRVGEG DKEDATRRFQ
    61  ILGKVYSVLS DREQRAVYDE QGTVDEDSPV LTQDRDWEAY WRLLFKKISL EDIQAFEKTY
   121  KGSEEELADI KQAYLDFKGD MDQIMESVLC VQYTEEPRIR NIIQQAIDAG EVPSYNAFVK
   181  ESKQKMNARK RRAQEEAKEA EMSRKELGLD EGVDSLKAAI QSRQKDRQKE MDNFLAQMEA
   241  KYCKSSKGGG KKSALKKEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 87 nTPM
thymus: 33 nTPM
tonsil: 30 nTPM
cerebellum: 29 nTPM
lymph node: 26 nTPM
retina: 23 nTPM

Single-cell type

erythrocyte progenitors: 257 nCPM
platelets: 154 nCPM
early spermatids: 146 nCPM
cytotrophoblasts: 141 nCPM
migrating cytotrophoblasts: 136 nCPM
extravillous trophoblasts: 135 nCPM

Immune cell

T-reg: 37 nTPM
memory B-cell: 33 nTPM
memory CD4 T-cell: 31 nTPM
naive CD4 T-cell: 30 nTPM
MAIT T-cell: 29 nTPM
eosinophil: 29 nTPM

Brain region

cerebellum: 17 nTPM
cerebral cortex: 16 nTPM
white matter: 14 nTPM
basal ganglia: 13 nTPM
hypothalamus: 13 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: -1.15
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DnaJ domain
DnaJ domain, conserved site
Chaperone J-domain superfamily
DnaJ domain
J domain-containing protein
DNAJC9, HTH domain
DNAJC9 HTH domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC9 as an antibody target. Whether an autoantibody or antibody against DNAJC9 could matter depends on whether native DNAJC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC9 is annotated at the cell surface, where native DNAJC9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DNAJC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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