DNAJC6

Protein identityUniProt · HPA

UniProt accession

O75061

Gene

DNAJC6

Ensembl

ENSG00000116675

Chromosome

1

Canonical length

913 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

913 residues, UniProt reviewed canonical sequence.

>O75061|DNAJC6
     1  MKDSENKGAS SPDMEPSYGG GLFDMVKGGA GRLFSNLKDN LKDTLKDTSS RVIQSVTSYT
    61  KGDLDFTYVT SRIIVMSFPL DNVDIGFRNQ VDDIRSFLDS RHLDHYTVYN LSPKSYRTAK
   121  FHSRVSECSW PIRQAPSLHN LFAVCRNMYN WLLQNPKNVC VVHCLDGRAA SSILVGAMFI
   181  FCNLYSTPGP AIRLLYAKRP GIGLSPSHRR YLGYMCDLLA DKPYRPHFKP LTIKSITVSP
   241  IPFFNKQRNG CRPYCDVLIG ETKIYSTCTD FERMKEYRVQ DGKIFIPLNI TVQGDVVVSM
   301  YHLRSTIGSR LQAKVTNTQI FQLQFHTGFI PLDTTVLKFT KPELDACDVP EKYPQLFQVT
   361  LDVELQPHDK VIDLTPPWEH YCTKDVNPSI LFSSHQEHQD TLALGGQAPI DIPPDNPRHY
   421  GQSGFFASLC WQDQKSEKSF CEEDHAALVN QESEQSDDEL LTLSSPHGNA NGDKPHGVKK
   481  PSKKQQEPAA PPPPEDVDLL GLEGSAMSNS FSPPAAPPTN SELLSDLFGG GGAAGPTQAG
   541  QSGVEDVFHP SGPASTQSTP RRSATSTSAS PTLRVGEGAT FDPFGAPSKP SGQDLLGSFL
   601  NTSSASSDPF LQPTRSPSPT VHASSTPAVN IQPDVSGGWD WHAKPGGFGM GSKSAATSPT
   661  GSSHGTPTHQ SKPQTLDPFA DLGTLGSSSF ASKPTTPTGL GGGFPPLSSP QKASPQPMGG
   721  GWQQGGAYNW QQPQPKPQPS MPHSSPQNRP NYNVSFSAMP GGQNERGKGS SNLEGKQKAA
   781  DFEDLLSGQG FNAHKDKKGP RTIAEMRKEE MAKEMDPEKL KILEWIEGKE RNIRALLSTM
   841  HTVLWAGETK WKPVGMADLV TPEQVKKVYR KAVLVVHPDK ATGQPYEQYA KMIFMELNDA
   901  WSEFENQGQK PLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

90 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAJC6.

Disease | AllUniProt

Conditions DNAJC6 is implicated in, by any mechanism.

• Parkinson disease 19A, juvenile-onset (PARK19A) MIM:615528
• Parkinson disease 19B, early-onset (PARK19B) MIM:615528

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 399 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Juvenile onset Parkinson disease 19A
• Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
• Prostate cancer
• Parkinson disease 19B, early-onset
• DNAJC6-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.22

gnomAD pLI

1

gnomAD missense Z

1.6

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• clathrin coat disassembly
• clathrin-dependent endocytosis
• intracellular transport
• regulation of clathrin coat assembly
• regulation of clathrin-dependent endocytosis
• synaptic vesicle recycling
• synaptic vesicle uncoating

Molecular functions

• clathrin binding
• clathrin heavy chain binding
• heat shock protein binding
• phosphoprotein phosphatase activity
• SH3 domain binding

Cellular components

• clathrin-coated vesicle
• cytoplasm
• cytosol
• extrinsic component of presynaptic endocytic zone membrane
• postsynaptic density
• vesicle

Protein domainsUniProt · Pfam · InterPro

• Tyrosine-specific protein phosphatases domain
• DnaJ domain
• Tensin phosphatase, C2 domain
• Protein-tyrosine phosphatase-like
• Tensin-type phosphatase domain
• C2 domain superfamily
• Chaperone J-domain superfamily
• C2 domain of PTEN tumour-suppressor protein

KeywordsUniProt

• Acetylation
• Chaperone
• Cytoplasmic vesicle
• Hydrolase
• Neurodegeneration
• Parkinson disease
• Parkinsonism
• Phosphoprotein
• Protein phosphatase
• Repeat
• SH3-binding

InteractionsUniProt · HPA

Protein binding partners of DNAJC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AP2A2
• CLTC
• DNM1
• HSPA8
• CLTA