Seroatlas · Human Serome Atlas

DNAJB14

DnaJ homolog subfamily B member 14

Also known as: DJB14_HUMAN, FLJ14281

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBM8
Gene: DNAJB14
Ensembl: ENSG00000164031
Chromosome: 4
Canonical length: 379 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables Hsp70 protein binding activity. Involved in chaperone cofactor-dependent protein refolding and protein-containing complex assembly. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>Q8TBM8|DNAJB14
     1  MEGNRDEAEK CVEIAREALN AGNREKAQRF LQKAEKLYPL PSARALLEII MKNGSTAGNS
    61  PHCRKPSGSG DQSKPNCTKD STSGSGEGGK GYTKDQVDGV LSINKCKNYY EVLGVTKDAG
   121  DEDLKKAYRK LALKFHPDKN HAPGATDAFK KIGNAYAVLS NPEKRKQYDL TGNEEQACNH
   181  QNNGRFNFHR GCEADITPED LFNIFFGGGF PSGSVHSFSN GRAGYSQQHQ HRHSGHEREE
   241  ERGDGGFSVF IQLMPIIVLI LVSLLSQLMV SNPPYSLYPR SGTGQTIKMQ TENLGVVYYV
   301  NKDFKNEYKG MLLQKVEKSV EEDYVTNIRN NCWKERQQKT DMQYAAKVYR DDRLRRKADA
   361  LSMDNCKELE RLTSLYKGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJB14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 20 nTPM
retina: 17 nTPM
bone marrow: 17 nTPM
thyroid gland: 16 nTPM
placenta: 16 nTPM
lymph node: 14 nTPM

Single-cell type

neutrophil progenitors: 206 nCPM
pituicytes/fscs: 161 nCPM
thyrotrophs: 160 nCPM
lactotrophs: 154 nCPM
corticotrophs: 154 nCPM
nk-cells: 147 nCPM

Immune cell

basophil: 39 nTPM
non-classical monocyte: 26 nTPM
neutrophil: 23 nTPM
T-reg: 20 nTPM
gdT-cell: 19 nTPM
eosinophil: 18 nTPM

Brain region

cerebral cortex: 46 nTPM
hypothalamus: 44 nTPM
white matter: 42 nTPM
pons: 41 nTPM
thalamus: 39 nTPM
midbrain: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.94
gnomAD missense Z: 1.69
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Hsp70 protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJB14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJB14 as an antibody target. Whether an autoantibody or antibody against DNAJB14 could matter depends on whether native DNAJB14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJB14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJB14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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