Seroatlas · Human Serome Atlas

CDKN1B

Cyclin-dependent kinase inhibitor 1B

Also known as: CDN1B_HUMAN, KIP1, P27KIP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46527
Gene: CDKN1B
Ensembl: ENSG00000111276
Chromosome: 12
Canonical length: 198 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Primary cilium,Primary cilium transition zone,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>P46527|CDKN1B
     1  MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW
    61  NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG
   121  APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN
   181  AGSVEQTPKK PGLRRRQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKN1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 100 nTPM
blood vessel: 83 nTPM
skeletal muscle: 76 nTPM
spinal cord: 75 nTPM
thymus: 67 nTPM
bone marrow: 64 nTPM

Single-cell type

neutrophils: 254 nCPM
müller glia: 188 nCPM
t-cells: 184 nCPM
retinal pigment epithelial cells: 158 nCPM
esophageal apical cells: 149 nCPM
plasma cells: 146 nCPM

Immune cell

neutrophil: 21 nTPM
T-reg: 12 nTPM
eosinophil: 8.2 nTPM
naive CD4 T-cell: 7.6 nTPM
memory CD4 T-cell: 7.5 nTPM
memory CD8 T-cell: 6.9 nTPM

Brain region

white matter: 149 nTPM
cerebellum: 115 nTPM
basal ganglia: 108 nTPM
pons: 90 nTPM
medulla oblongata: 87 nTPM
hypothalamus: 86 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDKN1B.

Disease | AllUniProt

Conditions CDKN1B is implicated in, by any mechanism.

Multiple endocrine neoplasia 4 (MEN4) MIM:610755

Disease | GeneticClinVar

119 pathogenic / likely-pathogenic of 1,119 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Multiple endocrine neoplasia type 4
Hereditary cancer-predisposing syndrome
Neuroendocrine neoplasm
Lung cancer
Neoplasm

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.62
gnomAD missense Z: -1.85
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDKN1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDKN1B as an antibody target. Whether an autoantibody or antibody against CDKN1B could matter depends on whether native CDKN1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDKN1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDKN1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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