IRAK1BP1
Interleukin-1 receptor-associated kinase 1-binding protein 1
Also known as: AIP70, IKBP1_HUMAN, SIMPL
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VVH5
- Gene
- IRAK1BP1
- Ensembl
- ENSG00000146243
- Chromosome
- 6
- Canonical length
- 260 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable signaling adaptor activity. Predicted to be involved in canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
260 residues, UniProt reviewed canonical sequence.
>Q5VVH5|IRAK1BP1
1 MSLQKTPPTR VFVELVPWAD RSRENNLASG RETLPGLRHP LSSTQAQTAT REVQVSGTSE
61 VSAGPDRAQV VVRVSSTKEA AAEAKKSVCR RLDYITQSLQ QQGVQAENIT VTKDFRRVEN
121 AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD SSVVISPPQF YHTPGSVENL RRQACLVAVE
181 NAWRKAQEVC NLVGQTLGKP LLIKEEETKE WEGQIDDHQS SRLSSSLTVQ QKIKSATIHA
241 ASKVFITFEV KGKEKRKKHLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IRAK1BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 5.2 nTPM
Expression across tissuesHPA
Tissue
- retina: 5.2 nTPM
- bone marrow: 5.1 nTPM
- epididymis: 4.1 nTPM
- testis: 3.7 nTPM
- parathyroid gland: 3.4 nTPM
- pituitary gland: 3.2 nTPM
Single-cell type
- brain inhibitory neurons: 162 nCPM
- choroid plexus epithelial cells: 158 nCPM
- ependymal cells: 144 nCPM
- thyrotrophs: 141 nCPM
- cardiomyocytes: 127 nCPM
- respiratory ciliated cells: 123 nCPM
Immune cell
- basophil: 1.1 nTPM
- naive CD4 T-cell: 0.4 nTPM
- naive CD8 T-cell: 0.4 nTPM
- neutrophil: 0.4 nTPM
- plasmacytoid DC: 0.4 nTPM
- T-reg: 0.4 nTPM
Brain region
- cerebellum: 29 nTPM
- cerebral cortex: 24 nTPM
- choroid plexus: 22 nTPM
- basal ganglia: 20 nTPM
- hippocampal formation: 20 nTPM
- hypothalamus: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.4
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.6
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Interleukin-1 receptor-associated kinase 1-binding protein 1/DUF541
- Interleukin-1 receptor-associated kinase 1-binding protein 1
- Protein of unknown function (DUF541)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of IRAK1BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IRAK1BP1 as an antibody target. Whether an autoantibody or antibody against IRAK1BP1 could matter depends on whether native IRAK1BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IRAK1BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IRAK1BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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