Seroatlas · Human Serome Atlas

SGTA

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Also known as: alphaSGT, hSGT, SGT, SGT1, SGTA_HUMAN, UBP, Vpu

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43765
Gene: SGTA
Ensembl: ENSG00000104969
Chromosome: 19
Canonical length: 313 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>O43765|SGTA
     1  MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE
    61  IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL
   121  NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA
   181  YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN
   241  PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR
   301  SRTPSASNDD QQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 95 nTPM
spinal cord: 83 nTPM
heart muscle: 82 nTPM
hippocampal formation: 69 nTPM
liver: 66 nTPM
cerebral cortex: 66 nTPM

Single-cell type

syncytiotrophoblasts: 131 nCPM
esophageal apical cells: 93 nCPM
early spermatids: 90 nCPM
late spermatids: 77 nCPM
migrating cytotrophoblasts: 73 nCPM
tuft cells: 69 nCPM

Immune cell

intermediate monocyte: 28 nTPM
non-classical monocyte: 28 nTPM
T-reg: 26 nTPM
myeloid DC: 24 nTPM
total PBMC: 22 nTPM
classical monocyte: 22 nTPM

Brain region

white matter: 69 nTPM
medulla oblongata: 68 nTPM
midbrain: 63 nTPM
spinal cord: 61 nTPM
cerebral cortex: 61 nTPM
thalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.95
gnomAD missense Z: 1.97
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SGTA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGTA as an antibody target. Whether an autoantibody or antibody against SGTA could matter depends on whether native SGTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGTA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SGTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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