Seroatlas · Human Serome Atlas

MLLT11

Protein AF1q

Also known as: AF1Q, AF1Q_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13015
Gene
MLLT11
Ensembl
ENSG00000213190
Chromosome
1
Canonical length
90 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>Q13015|MLLT11
     1  MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG QATAADQEKN
    61  PEGDGLLEYS TFNFWRAPIA SIHSFELDLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLLT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
132 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 132 nTPM
  • hypothalamus: 100 nTPM
  • cerebellum: 97 nTPM
  • amygdala: 83 nTPM
  • hippocampal formation: 67 nTPM
  • midbrain: 56 nTPM

Single-cell type

  • late spermatids: 365 nCPM
  • early spermatids: 94 nCPM
  • other brain neurons: 76 nCPM
  • brain excitatory neurons: 58 nCPM
  • brain inhibitory neurons: 46 nCPM
  • smooth muscle cells: 43 nCPM

Immune cell

  • naive CD8 T-cell: 9.1 nTPM
  • memory CD8 T-cell: 6.2 nTPM
  • gdT-cell: 5.9 nTPM
  • naive CD4 T-cell: 5.3 nTPM
  • T-reg: 4.1 nTPM
  • NK-cell: 4 nTPM

Brain region

  • cerebral cortex: 205 nTPM
  • hypothalamus: 171 nTPM
  • pons: 138 nTPM
  • basal ganglia: 122 nTPM
  • white matter: 114 nTPM
  • medulla oblongata: 106 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0.53
gnomAD missense Z
0.1
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLLT11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLLT11 as an antibody target. Whether an autoantibody or antibody against MLLT11 could matter depends on whether native MLLT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLLT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLLT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MLLT11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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