Seroatlas · Human Serome Atlas

MCL1

Induced myeloid leukemia cell differentiation protein Mcl-1

Also known as: BCL2L3, Mcl-1, MCL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q07820
Gene
MCL1
Ensembl
ENSG00000143384
Chromosome
1
Canonical length
350 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q07820|MCL1
     1  MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS
    61  AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM
   121  SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE
   181  IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE
   241  DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR
   301  TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
647 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 647 nTPM
  • liver: 378 nTPM
  • urinary bladder: 282 nTPM
  • gallbladder: 261 nTPM
  • adipose tissue: 260 nTPM
  • appendix: 250 nTPM

Single-cell type

  • neutrophils: 5,898 nCPM
  • monocytes: 1,779 nCPM
  • pancreatic acinar cells: 1,275 nCPM
  • esophageal apical cells: 1,210 nCPM
  • neutrophil progenitors: 1,190 nCPM
  • mast cells: 1,114 nCPM

Immune cell

  • neutrophil: 107 nTPM
  • eosinophil: 52 nTPM
  • T-reg: 30 nTPM
  • basophil: 23 nTPM
  • naive CD4 T-cell: 23 nTPM
  • classical monocyte: 20 nTPM

Brain region

  • thalamus: 109 nTPM
  • medulla oblongata: 97 nTPM
  • cerebral cortex: 94 nTPM
  • choroid plexus: 93 nTPM
  • hypothalamus: 88 nTPM
  • spinal cord: 86 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.96
gnomAD missense Z
-0.36
DepMap mean gene effect
-0.8
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCL1 as an antibody target. Whether an autoantibody or antibody against MCL1 could matter depends on whether native MCL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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