METTL21A
Protein N-lysine methyltransferase METTL21A
Also known as: FAM119A, HCA557b, HSPA-KMT, LOC151194, MT21A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WXB1
- Gene
- METTL21A
- Ensembl
- ENSG00000144401
- Chromosome
- 2
- Canonical length
- 218 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
218 residues, UniProt reviewed canonical sequence.
>Q8WXB1|METTL21A
1 MALVPYEETT EFGLQKFHKP LATFSFANHT IQIRQDWRHL GVAAVVWDAA IVLSTYLEMG
61 AVELRGRSAV ELGAGTGLVG IVAALLGAHV TITDRKVALE FLKSNVQANL PPHIQTKTVV
121 KELTWGQNLG SFSPGEFDLI LGADIIYLEE TFTDLLQTLE HLCSNHSVIL LACRIRYERD
181 NNFLAMLERQ FTVRKVHYDP EKDVHIYEAQ KRNQKEDLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against METTL21A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- liver: 23 nTPM
- bone marrow: 21 nTPM
- spinal cord: 19 nTPM
- midbrain: 18 nTPM
- basal ganglia: 17 nTPM
- cerebral cortex: 16 nTPM
Single-cell type
- cardiomyocytes: 157 nCPM
- mast cells: 126 nCPM
- late spermatids: 86 nCPM
- cdc: 85 nCPM
- neutrophil progenitors: 78 nCPM
- microglia: 76 nCPM
Immune cell
- eosinophil: 55 nTPM
- memory B-cell: 54 nTPM
- non-classical monocyte: 46 nTPM
- naive B-cell: 44 nTPM
- basophil: 31 nTPM
- plasmacytoid DC: 30 nTPM
Brain region
- choroid plexus: 26 nTPM
- white matter: 26 nTPM
- cerebellum: 25 nTPM
- midbrain: 25 nTPM
- medulla oblongata: 24 nTPM
- spinal cord: 24 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.36
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.04
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- ATPase binding
- heat shock protein binding
- Hsp70 protein binding
- protein methyltransferase activity
- protein-lysine N-methyltransferase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of METTL21A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads METTL21A as an antibody target. Whether an autoantibody or antibody against METTL21A could matter depends on whether native METTL21A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
METTL21A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label METTL21A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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