HTN3
Histatin-3
Also known as: HIS2, HIS3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P15516
- Gene
- HTN3
- Ensembl
- ENSG00000205649
- Chromosome
- 4
- Canonical length
- 51 aa
- Protein class
- Predicted secreted proteins, Transporters
- Secretome location
- Secreted to digestive system
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
Canonical amino-acid sequenceUniProt
51 residues, UniProt reviewed canonical sequence.
>P15516|HTN3
1 MKFFVFALIL ALMLSMTGAD SHAKRHHGYK RKFHEKHHSH RGYRSNYLYD NLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HTN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 127,660 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 127,660 nTPM
- pancreas: 116 nTPM
- heart muscle: 24 nTPM
- bone marrow: 18 nTPM
- placenta: 12 nTPM
- ovary: 10 nTPM
Single-cell type
- salivary acinar cells: 65,693 nCPM
- salivary myoepithelial cells: 29,550 nCPM
- neutrophils: 4,240 nCPM
- t-cells: 507 nCPM
- innate lymphoid cells: 359 nCPM
- salivary basal cells: 357 nCPM
Immune cell
- basophil: 0.4 nTPM
- neutrophil: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
Brain region
- cerebellum: 19 nTPM
- cerebral cortex: 18 nTPM
- white matter: 16 nTPM
- basal ganglia: 15 nTPM
- hippocampal formation: 14 nTPM
- amygdala: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.47
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- biomineral tissue development
- defense response to bacterium
- defense response to fungus
- innate immune response
- killing of cells of another organism
- positive regulation of fibroblast proliferation
- positive regulation of wound healing
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HTN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HTN3 as an antibody target. Whether an autoantibody or antibody against HTN3 could matter depends on whether native HTN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HTN3 is annotated as secreted, so native HTN3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label HTN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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