Seroatlas · Human Serome Atlas

TTC4

Tetratricopeptide repeat protein 4

Also known as: CNS1, FLJ41930, MGC5097, TTC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95801
Gene
TTC4
Ensembl
ENSG00000243725
Chromosome
1
Canonical length
387 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Intermediate filaments,Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>O95801|TTC4
     1  MEQPGQDPTS DDVMDSFLEK FQSQPYRGGF HEDQWEKEFE KVPLFMSRAP SEIDPRENPD
    61  LACLQSIIFD EERSPEEQAK TYKDEGNDYF KEKDYKKAVI SYTEGLKKKC ADPDLNAVLY
   121  TNRAAAQYYL GNFRSALNDV TAARKLKPCH LKAIIRGALC HLELKHFAEA VNWCDEGLQI
   181  DAKEKKLLEM RAKADKLKRI EQRDVRKANL KEKKERNQNE ALLQAIKARN IRLSEAACED
   241  EDSASEGLGE LFLDGLSTEN PHGARLSLDG QGRLSWPVLF LYPEYAQSDF ISAFHEDSRF
   301  IDHLMVMFGE TPSWDLEQKY CPDNLEVYFE DEDRAELYRV PAKSTLLQVL QHQRYFVKAL
   361  TPAFLVCVGS SPFCKNFLRG RKVYQIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 34 nTPM
  • tongue: 21 nTPM
  • spinal cord: 19 nTPM
  • heart muscle: 17 nTPM
  • choroid plexus: 15 nTPM
  • pituitary gland: 15 nTPM

Single-cell type

  • thyrotrophs: 7.3 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • thymic myoid cells: 5.4 nCPM
  • early primary spermatocytes: 5 nCPM
  • differentiating spermatogonia: 3.9 nCPM
  • paneth cells: 3.9 nCPM

Immune cell

  • NK-cell: 19 nTPM
  • naive CD4 T-cell: 16 nTPM
  • non-classical monocyte: 15 nTPM
  • MAIT T-cell: 15 nTPM
  • naive CD8 T-cell: 14 nTPM
  • intermediate monocyte: 14 nTPM

Brain region

  • white matter: 13 nTPM
  • spinal cord: 10 nTPM
  • pons: 9.9 nTPM
  • medulla oblongata: 9.8 nTPM
  • midbrain: 9.6 nTPM
  • hypothalamus: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0
gnomAD missense Z
0.25
DepMap mean gene effect
-0.55
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC4 as an antibody target. Whether an autoantibody or antibody against TTC4 could matter depends on whether native TTC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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