Seroatlas · Human Serome Atlas

BAG3

BAG family molecular chaperone regulator 3

Also known as: BAG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95817
Gene
BAG3
Ensembl
ENSG00000151929
Chromosome
10
Canonical length
575 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Basal body,Cytosol

OverviewNCBI Gene

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>O95817|BAG3
     1  MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN DPRVPSEGPK
    61  ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH EGAENRQVHP FHVYPQPGMQ
   121  RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ CGQVAAAAAA QPPASHGPER SQSPAASDCS
   181  SSSSSASLPS SGRSSLGSHQ LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY
   241  QTHQPVYHKI QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD
   301  RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP VSQKPPPPSE
   361  KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST APAEATPPKP GEAEAPPKHP
   421  GVLKVEAILE KVQGLEQAVD NFEGKKTDKK YLMIEEYLTK ELLALDSVDP EGRADVRQAR
   481  RDGVRKVQTI LEKLEQKAID VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG
   541  NAEDPHTETQ QPEATAAATS NPSSMTDTPG NPAAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
490 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 490 nTPM
  • tongue: 176 nTPM
  • heart muscle: 142 nTPM
  • esophagus: 82 nTPM
  • basal ganglia: 80 nTPM
  • blood vessel: 79 nTPM

Single-cell type

  • pancreatic duct cells: 592 nCPM
  • monocytes: 343 nCPM
  • epididymal efferent duct ciliated cells: 330 nCPM
  • pancreatic acinar cells: 324 nCPM
  • thymic myoid cells: 317 nCPM
  • smooth muscle cells: 300 nCPM

Immune cell

  • naive CD4 T-cell: 4.1 nTPM
  • memory CD4 T-cell: 2.4 nTPM
  • T-reg: 1.7 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • MAIT T-cell: 1.1 nTPM
  • memory CD8 T-cell: 0.8 nTPM

Brain region

  • medulla oblongata: 188 nTPM
  • hypothalamus: 184 nTPM
  • spinal cord: 144 nTPM
  • pons: 132 nTPM
  • midbrain: 131 nTPM
  • white matter: 121 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BAG3.

Disease | AllUniProt

Conditions BAG3 is implicated in, by any mechanism.

  • Myopathy, myofibrillar, 6 (MFM6) MIM:612954
  • Cardiomyopathy, dilated, 1HH (CMD1HH) MIM:613881
  • Neuronopathy, distal hereditary motor, autosomal dominant 15 (HMND15) MIM:621094
  • Charcot-Marie-Tooth disease, axonal, type 2JJ (CMT2JJ) MIM:621095

Disease | GeneticClinVar

156 pathogenic / likely-pathogenic of 1,383 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.62
gnomAD missense Z
-0.74
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAG3 as an antibody target. Whether an autoantibody or antibody against BAG3 could matter depends on whether native BAG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BAG3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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