Seroatlas · Human Serome Atlas

BCL2L1

Bcl-2-like protein 1

Also known as: B2CL1_HUMAN, Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q07817
Gene
BCL2L1
Ensembl
ENSG00000171552
Chromosome
20
Canonical length
233 aa
Protein class
Cancer-related genes, Predicted membrane proteins, RAS pathway related proteins, Transporters
Subcellular location
Nucleoli fibrillar center,Mitochondria,Acrosome
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q07817|BCL2L1
     1  MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA
    61  DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY
   121  QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP
   181  WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL2L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
108 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 108 nTPM
  • thymus: 104 nTPM
  • bone marrow: 93 nTPM
  • blood vessel: 89 nTPM
  • lung: 81 nTPM
  • kidney: 80 nTPM

Single-cell type

  • platelets: 420 nCPM
  • esophageal apical cells: 415 nCPM
  • alveolar cells type 1: 389 nCPM
  • choroid plexus epithelial cells: 336 nCPM
  • distal convoluted tubule cells: 295 nCPM
  • endometrial glandular cells: 283 nCPM

Immune cell

  • gdT-cell: 40 nTPM
  • MAIT T-cell: 31 nTPM
  • basophil: 29 nTPM
  • total PBMC: 28 nTPM
  • memory CD8 T-cell: 27 nTPM
  • eosinophil: 26 nTPM

Brain region

  • choroid plexus: 159 nTPM
  • white matter: 93 nTPM
  • thalamus: 89 nTPM
  • basal ganglia: 83 nTPM
  • pons: 79 nTPM
  • midbrain: 76 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BCL2L1.

Disease | ImmuneIEDB

Conditions an epitope on BCL2L1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.94
gnomAD missense Z
1.62
DepMap mean gene effect
-1.06
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL2L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL2L1 as an antibody target. Whether an autoantibody or antibody against BCL2L1 could matter depends on whether native BCL2L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL2L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL2L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCL2L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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