Seroatlas · Human Serome Atlas

TOMM70

Mitochondrial import receptor subunit TOM70

Also known as: KIAA0719, Tom70, TOM70_HUMAN, TOMM70A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94826
Gene
TOMM70
Ensembl
ENSG00000154174
Chromosome
3
Canonical length
608 aa
Protein class
Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]

Canonical amino-acid sequenceUniProt

608 residues, UniProt reviewed canonical sequence.

>O94826|TOMM70
     1  MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL LGAGAIYLWS
    61  RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE GPGAHLDMNS LDRAQAAKNK
   121  GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV
   181  ELNPKYVKAL FRRAKAHEKL DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA
   241  KEKYKNREPL MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK
   301  AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP DLDKVISLKE
   361  ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN ADVYHHRGQL KILLDQVEEA
   421  VADFDECIRL RPESALAQAQ KCFALYRQAY TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA
   481  LYAQALTDQQ QFGKADEMYD KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI
   541  DNKCDFAYET MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK
   601  YGLKPPTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOMM70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 71 nTPM
  • skeletal muscle: 62 nTPM
  • liver: 58 nTPM
  • basal ganglia: 49 nTPM
  • retina: 42 nTPM
  • heart muscle: 36 nTPM

Single-cell type

  • rod photoreceptor cells: 113 nCPM
  • brain inhibitory neurons: 109 nCPM
  • myonuclei: 106 nCPM
  • hepatocytes: 93 nCPM
  • gastric progenitor cells: 90 nCPM
  • adrenal medulla cells: 85 nCPM

Immune cell

  • NK-cell: 2.7 nTPM
  • naive CD8 T-cell: 2.5 nTPM
  • MAIT T-cell: 2.3 nTPM
  • memory CD4 T-cell: 2.3 nTPM
  • naive CD4 T-cell: 2.3 nTPM
  • memory B-cell: 2 nTPM

Brain region

  • basal ganglia: 81 nTPM
  • cerebral cortex: 49 nTPM
  • hypothalamus: 49 nTPM
  • pons: 46 nTPM
  • cerebellum: 43 nTPM
  • hippocampal formation: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOMM70 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOMM70 as an antibody target. Whether an autoantibody or antibody against TOMM70 could matter depends on whether native TOMM70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOMM70 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOMM70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TOMM70. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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