Seroatlas · Human Serome Atlas

TTC1

Tetratricopeptide repeat protein 1

Also known as: TPR1, TTC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99614
Gene
TTC1
Ensembl
ENSG00000113312
Chromosome
5
Canonical length
292 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q99614|TTC1
     1  MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE AHLQEDQGEE
    61  ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL EKNMSDEEKQ KRREESTRLK
   121  EEGNEQFKKG DYIEAESSYS RALEMCPSCF QKERSILFSN RAAARMKQDK KEMAINDCSK
   181  AIQLNPSYIR AILRRAELYE KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN
   241  ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 85 nTPM
  • midbrain: 72 nTPM
  • tongue: 72 nTPM
  • cerebral cortex: 71 nTPM
  • amygdala: 65 nTPM
  • hypothalamus: 63 nTPM

Single-cell type

  • oocytes: 313 nCPM
  • neutrophils: 188 nCPM
  • syncytiotrophoblasts: 170 nCPM
  • late primary spermatocytes: 167 nCPM
  • cytotrophoblasts: 166 nCPM
  • migrating cytotrophoblasts: 152 nCPM

Immune cell

  • total PBMC: 116 nTPM
  • eosinophil: 105 nTPM
  • basophil: 103 nTPM
  • neutrophil: 102 nTPM
  • memory B-cell: 94 nTPM
  • T-reg: 91 nTPM

Brain region

  • medulla oblongata: 65 nTPM
  • pons: 58 nTPM
  • cerebellum: 51 nTPM
  • midbrain: 50 nTPM
  • hypothalamus: 47 nTPM
  • cerebral cortex: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TTC1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
-1.11
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC1 as an antibody target. Whether an autoantibody or antibody against TTC1 could matter depends on whether native TTC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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