Seroatlas · Human Serome Atlas

LRWD1

Leucine-rich repeat and WD repeat-containing protein 1

Also known as: CENP-33, DKFZp434K1815, LRWD1_HUMAN, ORCA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UFC0
Gene
LRWD1
Ensembl
ENSG00000161036
Chromosome
7
Canonical length
647 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Vesicles

OverviewNCBI Gene

The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>Q9UFC0|LRWD1
     1  MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LELLSEHLDP KLLCRLTQLQ ELDLSNNHLE
    61  TLPDNLGLSH LRVLRCANNQ LGDVTALCQF PKLEELSLEG NPFLTVNDNL KVSFLLPTLR
   121  KVNGKDASST YSQVENLNRE LTSRVTAHWE KFMATLGPEE EAEKAQADFV KSAVRDVRYG
   181  PESLSEFTQW RVRMISEELV AASRTQVQKA NSPEKPPEAG AAHKPRARLA ALKRPDDVPL
   241  SLSPSKRACA SPSAQVEGSP VAGSDGSQPA VKLEPLHFLQ CHSKNNSPQD LETQLWACAF
   301  EPAWEEGATS QTVATCGGEA VCVIDCQTGI VLHKYKAPGE EFFSVAWTAL MVVTQAGHKK
   361  RWSVLAAAGL RGLVRLLHVR AGFCCGVIRA HKKAIATLCF SPAHETHLFT ASYDKRIILW
   421  DIGVPNQDYE FQASQLLTLD TTSIPLRLCP VASCPDARLL AGCEGGCCCW DVRLDQPQKR
   481  RVCEVEFVFS EGSEASGRRV DGLAFVNEDI VASKGSGLGT ICLWSWRQTW GGRGSQSTVA
   541  VVVLARLQWS STELAYFSLS ACPDKGIVLC GDEEGNVWLY DVSNILKQPP LLPAALQAPT
   601  QILKWPQPWA LGQVVTKTMV NTVVANASFT YLTALTDSNI VAIWGRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRWD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
272 nTPM

Expression across tissuesHPA

Tissue

  • testis: 272 nTPM
  • cerebellum: 28 nTPM
  • spleen: 24 nTPM
  • pituitary gland: 17 nTPM
  • adrenal gland: 17 nTPM
  • small intestine: 17 nTPM

Single-cell type

  • late primary spermatocytes: 1,786 nCPM
  • early spermatids: 898 nCPM
  • early primary spermatocytes: 172 nCPM
  • late spermatids: 150 nCPM
  • oocytes: 147 nCPM
  • respiratory ciliated cells: 104 nCPM

Immune cell

  • naive B-cell: 12 nTPM
  • basophil: 11 nTPM
  • NK-cell: 11 nTPM
  • memory B-cell: 10 nTPM
  • eosinophil: 9.9 nTPM
  • gdT-cell: 9.7 nTPM

Brain region

  • midbrain: 25 nTPM
  • hippocampal formation: 21 nTPM
  • medulla oblongata: 20 nTPM
  • thalamus: 20 nTPM
  • pons: 19 nTPM
  • cerebral cortex: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
-0.23
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRWD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRWD1 as an antibody target. Whether an autoantibody or antibody against LRWD1 could matter depends on whether native LRWD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRWD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRWD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRWD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...