Seroatlas · Human Serome Atlas

DCAF5

DDB1- and CUL4-associated factor 5

Also known as: BCRG2, BCRP2, D14S1461E, DCAF5_HUMAN, KIAA1824, WDR22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JK2
Gene: DCAF5
Ensembl: ENSG00000139990
Chromosome: 14
Canonical length: 942 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in negative regulation of fatty acid biosynthetic process. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

942 residues, UniProt reviewed canonical sequence.

>Q96JK2|DCAF5
     1  MKRRAGLGGS MRSVVGFLSQ RGLHGDPLLT QDFQRRRLRG CRNLYKKDLL GHFGCVNAIE
    61  FSNNGGQWLV SGGDDRRVLL WHMEQAIHSR VKPIQLKGEH HSNIFCLAFN SGNTKVFSGG
   121  NDEQVILHDV ESSETLDVFA HEDAVYGLSV SPVNDNIFAS SSDDGRVLIW DIRESPHGEP
   181  FCLANYPSAF HSVMFNPVEP RLLATANSKE GVGLWDIRKP QSSLLRYGGN LSLQSAMSVR
   241  FNSNGTQLLA LRRRLPPVLY DIHSRLPVFQ FDNQGYFNSC TMKSCCFAGD RDQYILSGSD
   301  DFNLYMWRIP ADPEAGGIGR VVNGAFMVLK GHRSIVNQVR FNPHTYMICS SGVEKIIKIW
   361  SPYKQPGCTG DLDGRIEDDS RCLYTHEEYI SLVLNSGSGL SHDYANQSVQ EDPRMMAFFD
   421  SLVRREIEGW SSDSDSDLSE STILQLHAGV SERSGYTDSE SSASLPRSPP PTVDESADNA
   481  FHLGPLRVTT TNTVASTPPT PTCEDAASRQ QRLSALRRYQ DKRLLALSNE SDSEENVCEV
   541  ELDTDLFPRP RSPSPEDESS SSSSSSSSED EEELNERRAS TWQRNAMRRR QKTTREDKPS
   601  APIKPTNTYI GEDNYDYPQI KVDDLSSSPT SSPERSTSTL EIQPSRASPT SDIESVERKI
   661  YKAYKWLRYS YISYSNNKDG ETSLVTGEAD EGRAGTSHKD NPAPSSSKEA CLNIAMAQRN
   721  QDLPPEGCSK DTFKEETPRT PSNGPGHEHS SHAWAEVPEG TSQDTGNSGS VEHPFETKKL
   781  NGKALSSRAE EPPSPPVPKA SGSTLNSGSG NCPRTQSDDS EERSLETICA NHNNGRLHPR
   841  PPHPHNNGQN LGELEVVAYS SPGHSDTDRD NSSLTGTLLH KDCCGSEMAC ETPNAGTRED
   901  PTDTPATDSS RAVHGHSGLK RQRIELEDTD SENSSSEKKL KT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 70 nTPM
testis: 57 nTPM
tongue: 49 nTPM
thymus: 37 nTPM
blood vessel: 35 nTPM
parathyroid gland: 34 nTPM

Single-cell type

sertoli cells: 284 nCPM
early spermatids: 210 nCPM
somatotrophs: 185 nCPM
thyrotrophs: 181 nCPM
lactotrophs: 178 nCPM
adrenal cortex cells: 170 nCPM

Immune cell

NK-cell: 32 nTPM
gdT-cell: 31 nTPM
MAIT T-cell: 26 nTPM
memory CD8 T-cell: 23 nTPM
basophil: 21 nTPM
naive CD8 T-cell: 20 nTPM

Brain region

cerebral cortex: 43 nTPM
choroid plexus: 39 nTPM
hypothalamus: 39 nTPM
hippocampal formation: 38 nTPM
pons: 38 nTPM
thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 2.88
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF5 as an antibody target. Whether an autoantibody or antibody against DCAF5 could matter depends on whether native DCAF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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