Seroatlas · Human Serome Atlas

NUP43

Nucleoporin Nup43

Also known as: bA350J20.1, FLJ13287, NUP43_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFH3
Gene
NUP43
Ensembl
ENSG00000120253
Chromosome
6
Canonical length
380 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q8NFH3|NUP43
     1  MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG DFGNLDSDGG
    61  FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF LHHPNNQTLS VNQQWTTAHY
   121  HTGPGSPSYS SAPCTGVVCN NPEIVTVGED GRINLFRADH KEAVRTIDNA DSSTLHAVTF
   181  LRTPEILTVN SIGQLKIWDF RQQGNEPSQI LSLTGDRVPL HCVDRHPNQQ HVVATGGQDG
   241  MLSIWDVRQG TMPVSLLKAH EAEMWEVHFH PSNPEHLFTC SEDGSLWHWD ASTDVPEKSS
   301  LFHQGGRSST FLSHSISNQA NVHQSVISSW LSTDPAKDRI EITSLLPSRS LSVNTLDVLG
   361  PCLVCGTDAE AIYVTRHLFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 16 nTPM
  • lymph node: 15 nTPM
  • skeletal muscle: 13 nTPM
  • spleen: 13 nTPM
  • breast: 13 nTPM
  • skin: 13 nTPM

Single-cell type

  • late spermatids: 120 nCPM
  • erythrocyte progenitors: 58 nCPM
  • early spermatids: 47 nCPM
  • sertoli cells: 45 nCPM
  • megakaryocyte progenitors: 42 nCPM
  • megakaryocyte-erythroid progenitors: 40 nCPM

Immune cell

  • naive B-cell: 6.2 nTPM
  • intermediate monocyte: 5.4 nTPM
  • naive CD8 T-cell: 5.4 nTPM
  • plasmacytoid DC: 4.9 nTPM
  • classical monocyte: 4.8 nTPM
  • T-reg: 4.8 nTPM

Brain region

  • white matter: 17 nTPM
  • basal ganglia: 15 nTPM
  • cerebellum: 15 nTPM
  • medulla oblongata: 15 nTPM
  • hypothalamus: 14 nTPM
  • thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
-0.97
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP43 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP43 as an antibody target. Whether an autoantibody or antibody against NUP43 could matter depends on whether native NUP43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP43. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...