Seroatlas · Human Serome Atlas

TP53

Cellular tumor antigen p53

Also known as: LFS1, p53, P53_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04637
Gene
TP53
Ensembl
ENSG00000141510
Chromosome
17
Canonical length
393 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>P04637|TP53
     1  MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
    61  DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
   121  SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
   181  RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
   241  SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
   301  PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
   361  GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 44 nTPM
  • tonsil: 43 nTPM
  • skin: 35 nTPM
  • lymph node: 32 nTPM
  • fallopian tube: 30 nTPM
  • spleen: 29 nTPM

Single-cell type

  • paneth cells: 93 nCPM
  • enteric stem cells: 85 nCPM
  • enteric transient amplifying cells: 73 nCPM
  • breast myoepithelial cells: 71 nCPM
  • erythrocyte progenitors: 69 nCPM
  • esophageal basal cells: 67 nCPM

Immune cell

  • myeloid DC: 31 nTPM
  • plasmacytoid DC: 27 nTPM
  • intermediate monocyte: 22 nTPM
  • memory B-cell: 22 nTPM
  • classical monocyte: 21 nTPM
  • non-classical monocyte: 20 nTPM

Brain region

  • medulla oblongata: 47 nTPM
  • midbrain: 37 nTPM
  • spinal cord: 35 nTPM
  • basal ganglia: 34 nTPM
  • pons: 34 nTPM
  • thalamus: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TP53.

Disease | AllUniProt

Conditions TP53 is implicated in, by any mechanism.

Disease | GeneticClinVar

1,140 pathogenic / likely-pathogenic of 3,892 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on TP53 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against TP53 are reported. Each links to that disease's full target list.

Showing 10 of 23 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for TP53 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

237 publications

Show 20 more of 237 total

Reference: B cellIEDB

1 publication

Reference: T cellIEDB

34 publications

Show 20 more of 34 total

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.53
gnomAD missense Z
0.98
DepMap mean gene effect
0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TP53 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53 as an antibody target. Whether an autoantibody or antibody against TP53 could matter depends on whether native TP53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TP53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TP53. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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